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Tbio
TDG
G/T mismatch-specific thymine DNA glycosylase

Protein Summary
Description
DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392872
  • ENSP00000376611
  • ENSG00000139372

Symbol
  • hTDG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.9
transcription factor perturbation
0.88
virus perturbation
0.76
transcription factor
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.38   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 363   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.38   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
2
0
3.2
88.3
heel bone mineral density
2
2
2
65.7
vascular cell adhesion molecule-1 measurement
1
1
1
61
intraocular pressure measurement
1
1
1
57.3
corneal topography
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3.2
88.3
heel bone mineral density
2
65.7
vascular cell adhesion molecule-1 measurement
1
61
intraocular pressure measurement
1
57.3
corneal topography
1
42.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
thymine DNA glycosylase
700061
Mouse
MGI:108247
21665
Rat
RGD:620959
114521
Dog
thymine DNA glycosylase
VGNC:47216
475448
Horse
thymine DNA glycosylase
VGNC:23970
100053458
Species
Name
OMA
EggNOG
Inparanoid
Macaque
thymine DNA glycosylase
Mouse
Rat
Dog
thymine DNA glycosylase
Horse
thymine DNA glycosylase
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13569-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged pyrimidine
Reactome
DNA Repair
Reactome
Depyrimidination
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged pyrimidine
DNA Repair
Depyrimidination
Gene Ontology Terms (36)
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Protein-Protein Interactions (107)
1 – 10 of 107
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.996
Data Source:  Reactome,STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.993
Data Source:  Reactome,STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.982
Data Source:  Reactome,STRINGDB
SUMO3
Tbio
Novelty:  0.03096465
Score:  0.959
Data Source:  Reactome,STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.957
Data Source:  Reactome,STRINGDB
TET1
Tbio
Family:  Enzyme
Novelty:  0.00239645
Score:  0.887
Data Source:  STRINGDB
CA2
Tclin
Family:  Enzyme
Novelty:  0.00040118
Score:  0.874
Data Source:  STRINGDB
GADD45A
Tbio
Novelty:  0.00178533
Score:  0.871
Data Source:  STRINGDB
AICDA
Tbio
Family:  Enzyme
Novelty:  0.00132033
Score:  0.86
Data Source:  STRINGDB
SMUG1
Tbio
Family:  Enzyme
Novelty:  0.01345774
Score:  0.857
Data Source:  STRINGDB
Publication Statistics
PubMed Score  389.38

PubMed score by year
PubTator Score  154.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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