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Tbio
IRF5
Interferon regulatory factor 5

Protein Summary
Description
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249375
  • ENSP00000249375
  • ENSG00000128604
  • ENST00000357234
  • ENSP00000349770
  • ENST00000402030
  • ENSP00000385352
  • ENST00000465603
  • ENSP00000418534
  • ENST00000473745
  • ENSP00000419149
  • ENST00000477535
  • ENSP00000419950
  • ENST00000489702
  • ENSP00000418037
  • ENST00000619830
  • ENSP00000483292

Symbol
  • SLEB10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.82
biological process
0.77
disease
0.76
transcription factor
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.87   (req: < 5)
Gene RIFs: 178   (req: <= 3)
Antibodies: 541   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.87   (req: >= 5)
Gene RIFs: 178   (req: > 3)
Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.8
97.3
3
3
2
1.1
86.7
eosinophil count
2
2
2
80.4
1
1
0
1.2
76.7
1
1
0
1.2
76.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
97.3
2
1.1
86.7
eosinophil count
2
80.4
0
1.2
76.7
0
1.2
76.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (55)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Interferon gamma signaling
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (308)
1 – 10 of 308
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.969
Data Source: STRINGDB
MX2
Tbio
Novelty: 0.00139073
Score: 0.964
Data Source: STRINGDB
TRIM21
Tbio
Family: Enzyme
Novelty: 0.00069504
Score: 0.963
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.956
Data Source: STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.954
Data Source: STRINGDB
STAT2
Tbio
Family: TF
Novelty: 0.00241454
Score: 0.954
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.951
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.951
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.951
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  342.87

PubMed score by year
PubTator Score  227.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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