Tbio IRF5 Interferon regulatory factor 5

Protein Summary

Description

Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q13568
• A4D1J8
• A8DUA8
• A8DUA9
• E7EQ16
• E7EW54
• Q1A7B4
• Q64GA9
• Q64GB1
• Q64GB2
• Q6RCM8
• Q9BQF0
• IRF-5

Gene Name

• IRF5

Ensembl ID

• ENST00000249375
• ENSP00000249375
• ENSG00000128604
• ENST00000357234
• ENSP00000349770
• ENST00000402030
• ENSP00000385352
• ENST00000465603
• ENSP00000418534
• ENST00000473745
• ENSP00000419149
• ENST00000477535
• ENSP00000419950
• ENST00000489702
• ENSP00000418037
• ENST00000619830
• ENSP00000483292

Symbol

• SLEB10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
PubMedID	0.82
biological process	0.77
disease	0.76
transcription factor	0.69

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Interferon Regulatory Factor 5

Protein / Nucleic Acid Binding / Interferon Regulatory Factor 5

Protein / ... / Winged Helix/forkhead Transcription Factor / Interferon Regulatory Factor 5

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Interferon Regulatory Factor 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.51   (req: < 5)

Gene RIFs: 223   (req: <= 3)

Antibodies: 541   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.51   (req: >= 5)

Gene RIFs: 223   (req: > 3)

Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0