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Tbio
IRF5
Interferon regulatory factor 5

Protein Summary
Description
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249375
  • ENSP00000249375
  • ENSG00000128604
  • ENST00000357234
  • ENSP00000349770
  • ENST00000402030
  • ENSP00000385352
  • ENST00000465603
  • ENSP00000418534
  • ENST00000473745
  • ENSP00000419149
  • ENST00000477535
  • ENSP00000419950
  • ENST00000489702
  • ENSP00000418037
  • ENST00000619830
  • ENSP00000483292

Symbol
  • SLEB10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.82
biological process
0.77
disease
0.76
transcription factor
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.51   (req: < 5)
Gene RIFs: 216   (req: <= 3)
Antibodies: 541   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.51   (req: >= 5)
Gene RIFs: 216   (req: > 3)
Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0