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Tchem
NAE1
NEDD8-activating enzyme E1 regulatory subunit

Protein Classes
Protein Summary
Description
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290810
  • ENSP00000290810
  • ENSG00000159593
  • ENST00000359087
  • ENSP00000351990
  • ENST00000379463
  • ENSP00000368776
  • ENST00000394074
  • ENSP00000377637

Symbol
  • APPBP1
  • HPP1
  • ula-1
  • APPBP1
  • A-116A10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
co-expressed gene
0.89
kinase perturbation
0.88
transcription factor binding site profile
0.8
gene perturbation
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.16   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.16   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2
2
53.4
high density lipoprotein cholesterol measurement
1
2
2
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
53.4
high density lipoprotein cholesterol measurement
2
48.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NEDD8 activating enzyme E1 subunit 1
VGNC:9090
467995
Macaque
NEDD8 activating enzyme E1 subunit 1
696429
Mouse
MGI:2384561
234664
Rat
RGD:619945
84019
Dog
NEDD8 activating enzyme E1 subunit 1
VGNC:43607
610026
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NEDD8 activating enzyme E1 subunit 1
Macaque
NEDD8 activating enzyme E1 subunit 1
Mouse
Rat
Dog
NEDD8 activating enzyme E1 subunit 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13564-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Protein-Protein Interactions (229)
1 – 10 of 229
UBE2M
Tbio
Novelty: 0.02353106
p_int: 0.999959033
p_ni: 0.000040967
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.999256881
p_ni: 0.000743119
Data Source: BioPlex
ZBTB44
Tdark
Family: TF
Novelty: 0.75195191
p_int: 0.989275648
p_ni: 0.010724352
Score: 0.559
Data Source: BioPlex,STRINGDB
UBA3
Tbio
Novelty: 0.03962261
p_int: 0.778184161
p_ni: 0.221815839
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.996
Data Source: Reactome,STRINGDB
UBE2F
Tbio
Novelty: 0.06951245
Score: 0.992
Data Source: Reactome,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.988
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.978
Data Source: STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
Score: 0.972
Data Source: STRINGDB
RNF7
Tbio
Novelty: 0.02532658
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.16

PubMed score by year
PubTator Score  23.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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