Protein Classes
Protein Summary
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Can also form a functional, homotetrameric ion channel (PubMed:29899465). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with P ...more
- ENST00000237596
- ENSP00000237596
- ENSG00000118762
- TRPP2
- PC2
- PKD4
- Pc-2
- APKD2
- TRPP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
microRNA | 0.82 | ||
cell type or tissue | 0.81 | ||
kinase | 0.78 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 498.17 (req: < 5)
Gene RIFs: 156 (req: <= 3)
Antibodies: 302 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 498.17 (req: >= 5)
Gene RIFs: 156 (req: > 3)
Antibodies: 302 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 75
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cargo trafficking to the periciliary membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | VxPx cargo-targeting to cilium | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cargo trafficking to the periciliary membrane | ||||
Cilium Assembly | ||||
Organelle biogenesis and maintenance | ||||
VxPx cargo-targeting to cilium | ||||
Gene Ontology Terms (97)
Functions (21)
Components (22)
Processes (54)
Items per page:
10
1 – 10 of 21
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Protein-Protein Interactions (141)
1 – 10 of 141
PKD2L2
Family: IC
Novelty: 0.17366136
p_int: 0.999988736
p_ni: 0.000011264
Score: 0.221
Data Source: BioPlex,STRINGDB
COG7
Novelty: 0.10023573
p_int: 0.999985303
p_ni: 0.000014697
Data Source: BioPlex
FAM3D
Novelty: 0.04514362
p_int: 0.999924722
p_ni: 0.000075278
Score: 0.455
Data Source: BioPlex,STRINGDB
PICK1
Novelty: 0.00686801
p_int: 0.999915865
p_ni: 0.000084135
Data Source: BioPlex
ATP6V1D
Family: Enzyme
Novelty: 0.03173315
p_int: 0.99955135
p_ni: 0.000448644
p_wrong: 6e-9
Data Source: BioPlex
CYP2J2
Novelty: 0.00634057
p_int: 0.999189282
p_ni: 0.000810718
Data Source: BioPlex
BCAS4
Novelty: 0.15459088
p_int: 0.999170247
p_ni: 0.000829753
Score: 0.187
Data Source: BioPlex,STRINGDB
PTGIR
Family: GPCR
Novelty: 0.00497212
p_int: 0.999120623
p_ni: 0.000879377
Data Source: BioPlex
CRYL1
Family: Enzyme
Novelty: 0.02941898
p_int: 0.998234404
p_ni: 0.001765596
Data Source: BioPlex
CHRND
Family: IC
Novelty: 0.04863852
p_int: 0.998047563
p_ni: 0.001952437
Score: 0.229
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 498.17
PubMed score by year
PubTator Score 587.15
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAARDPPAG
1-70
AAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRG
70-140
LGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESS
140-210
TNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFW
210-280
KFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSV
280-350
SSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR
350-420
ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVE
420-490
EILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNN
490-560
IAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQ
560-630
ECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMEL
630-700
SDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQEL
700-770
TEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQ
770-840
VLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVR
840-910
EELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVHV
910-968
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVHV
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