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Tchem
PKD2
Polycystin-2

Protein Summary
Description
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Can also form a functional, homotetrameric ion channel (PubMed:29899465). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237596
  • ENSP00000237596
  • ENSG00000118762

Symbol
  • TRPP2
  • PC2
  • PKD4
  • Pc-2
  • APKD2
  • TRPP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
microRNA
0.82
cell type or tissue
0.81
kinase
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.38   (req: < 5)
Gene RIFs: 156   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.38   (req: >= 5)
Gene RIFs: 156   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 75
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (141)
PKD2L2
Tbio
Family:  IC
Novelty:  0.12399184
p_int:  0.999988736
p_ni:  0.000011264
Score:  0.221
Data Source:  BioPlex,STRINGDB
COG7
Tbio
Novelty:  0.07137701
p_int:  0.999985303
p_ni:  0.000014697
Data Source:  BioPlex
FAM3D
Tbio
Novelty:  0.11834339
p_int:  0.999924722
p_ni:  0.000075278
Score:  0.455
Data Source:  BioPlex,STRINGDB
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.999915865
p_ni:  0.000084135
Data Source:  BioPlex
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.99955135
p_ni:  0.000448644
p_wrong:  6e-9
Data Source:  BioPlex
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.999189282
p_ni:  0.000810718
Data Source:  BioPlex
BCAS4
Tbio
Novelty:  0.11759439
p_int:  0.999170247
p_ni:  0.000829753
Score:  0.187
Data Source:  BioPlex,STRINGDB
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.999120623
p_ni:  0.000879377
Data Source:  BioPlex
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.998234404
p_ni:  0.001765596
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.998047563
p_ni:  0.001952437
Score:  0.229
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
VxPx cargo-targeting to cilium
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
VxPx cargo-targeting to cilium
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (97)
Find Similar Targets
Items per page:
10
1 – 10 of 21
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
13
16
26
6
99.9
uric acid measurement
13
8
18
1.9
99.4
15
8
0
1.9
99.2
coffee consumption measurement
3
3
3
91.6
tea consumption measurement
2
2
2
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
26
6
99.9
uric acid measurement
18
1.9
99.4
0
1.9
99.2
coffee consumption measurement
3
91.6
tea consumption measurement
2
89
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polycystin 2, transient receptor potential cation channel
VGNC:7424
461367
Macaque
polycystin 2, transient receptor potential cation channel
702179
Mouse
MGI:1099818
18764
Rat
RGD:1559992
498328
Dog
polycystin 2, transient receptor potential cation channel
VGNC:44600
487852
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polycystin 2, transient receptor potential cation channel
Macaque
polycystin 2, transient receptor potential cation channel
Mouse
Rat
Dog
polycystin 2, transient receptor potential cation channel
Publication Statistics
PubMed Score 364.38
PubMed score by year
PubTator Score 587.15
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title