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Tbio
NEUROD1
Neurogenic differentiation factor 1

Protein Summary
Description
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By si ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295108
  • ENSP00000295108
  • ENSG00000162992

Symbol
  • BHLHA3
  • NEUROD
  • BETA2
  • BHF-1
  • MODY6
  • NEUROD
  • bHLHa3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.99
hub protein
0.75
PubMedID
0.71
gene perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.21   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.21   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Glycosuria
2
1
0
19.9
46.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Glycosuria
0
19.9
46.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neuronal differentiation 1
704954
Mouse
MGI:1339708
18012
Rat
RGD:3165
29458
Horse
neuronal differentiation 1
VGNC:20692
100067943
Cow
neuronal differentiation 1
VGNC:32017
539487
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neuronal differentiation 1
Mouse
Rat
Horse
neuronal differentiation 1
Cow
neuronal differentiation 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13562-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in beta cells
Reactome
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in beta cells
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Gene Ontology Terms (45)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (211)
1 – 10 of 211
TCF3
Tbio
Family: TF
Novelty: 0.00112675
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.975
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
p_int: 0.999999881
p_ni: 1.18e-7
p_wrong: 1e-9
Score: 0.937
Data Source: BioPlex,STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00381424
p_int: 0.999999585
p_ni: 4.15e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
DPF3
Tbio
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999999148
p_ni: 7.72e-7
p_wrong: 8e-8
Score: 0.224
Data Source: BioPlex,STRINGDB
LACRT
Tbio
Novelty: 0.03333799
p_int: 0.980369555
p_ni: 0.019623226
p_wrong: 0.000007219
Score: 0.177
Data Source: BioPlex,STRINGDB
GCK
Tchem
Family: Kinase
Novelty: 0.00112778
Score: 0.965
Data Source: STRINGDB
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
Score: 0.925
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.893
Data Source: STRINGDB
NKX2-2
Tbio
Family: TF
Novelty: 0.00608835
Score: 0.867
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.85
Data Source: STRINGDB
Publication Statistics
PubMed Score  509.21

PubMed score by year
PubTator Score  218.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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