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Tbio
DCTN2
Dynactin subunit 2

Protein Summary
Description
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434715
  • ENSP00000408910
  • ENSG00000175203
  • ENST00000543672
  • ENSP00000439376
  • ENST00000548249
  • ENSP00000447824

Symbol
  • DCTN50
  • RBP50
  • DCTN50
  • HEL-S-77
  • DYNAMITIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
co-expressed gene
0.85
cellular component
0.79
transcription factor binding site profile
0.74
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.23   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.23   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (35)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Anchoring of the basal body to the plasma membrane
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Gene Ontology Terms (25)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (397)
1 – 10 of 397
ACTR1B
Tbio
Novelty: 0.10014723
p_int: 0.999999993
p_ni: 7e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
p_int: 0.999999934
p_ni: 6.6e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty: 0.30624393
p_int: 0.99999926
p_ni: 7.4e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR10
Tbio
Novelty: 0.11388846
p_int: 0.999998333
p_ni: 0.000001666
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.99999785
p_ni: 0.00000215
Score: 0.53
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.999976323
p_ni: 0.000023675
p_wrong: 2e-9
Data Source: BioPlex
CCDC138
Tdark
Novelty: 4.02014418
p_int: 0.999953993
p_ni: 0.000010544
p_wrong: 0.000035463
Score: 0.211
Data Source: BioPlex,STRINGDB
DCTN4
Tbio
Novelty: 0.10319227
p_int: 0.999948238
p_ni: 0.000051762
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
DCTN3
Tbio
Novelty: 0.14551388
p_int: 0.999916035
p_ni: 0.000083965
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
DCTN5
Tdark
Novelty: 0.19530162
p_int: 0.999413
p_ni: 0.000587
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  81.23

PubMed score by year
PubTator Score  53.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer