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Tchem
CAMK2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296402
  • ENSP00000296402
  • ENSG00000145349
  • ENST00000342666
  • ENSP00000339740
  • ENST00000379773
  • ENSP00000369098
  • ENST00000394522
  • ENSP00000378030
  • ENST00000394524
  • ENSP00000378032
  • ENST00000508738
  • ENSP00000422566
  • ENST00000515496
  • ENSP00000423482

Symbol
  • CAMKD
  • CAMKD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug perturbation
1
molecular function
1
transcription factor perturbation
0.99
hub protein
0.98


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.74   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.74   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
75.2
electrocardiography
1
1
7
60.6
2
2
0
1.2
50.5
small vessel stroke
1
1
0
1.3
36.7
TPE interval measurement
1
1
1
34.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
75.2
electrocardiography
7
60.6
0
1.2
50.5
small vessel stroke
0
1.3
36.7
TPE interval measurement
1
34.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase II delta
VGNC:10381
461445
Macaque
calcium/calmodulin dependent protein kinase II delta
702504
Mouse
MGI:1341265
108058
Rat
RGD:2263
24246
Dog
calcium/calmodulin dependent protein kinase II delta
610764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase II delta
Macaque
calcium/calmodulin dependent protein kinase II delta
Mouse
Rat
Dog
calcium/calmodulin dependent protein kinase II delta
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13557-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (109)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 60
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Ca-dependent events
Reactome
CaM pathway
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Ca-dependent events
CaM pathway
Gene Ontology Terms (52)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (209)
1 – 10 of 209
CAMK2A
Tchem
Family: Kinase
Novelty: 0.00534906
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CAMK2B
Tchem
Family: Kinase
Novelty: 0.00793595
p_int: 0.999999995
p_ni: 5e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CAMK2G
Tchem
Family: Kinase
Novelty: 0.04642387
p_int: 0.999998506
p_ni: 0.000001494
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
DNAH14
Tdark
Novelty: 0.28289652
p_int: 0.999993319
p_ni: 0.000006614
p_wrong: 6.7e-8
Data Source: BioPlex
UNG
Tbio
Family: Enzyme
Novelty: 0.00268354
p_int: 0.999989577
p_ni: 3.5e-8
p_wrong: 0.000010388
Score: 0.222
Data Source: BioPlex,STRINGDB
BAP1
Tbio
Family: Enzyme
Novelty: 0.00501435
p_int: 0.99997876
p_ni: 0.000021239
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
KANSL3
Tbio
Novelty: 0.00150009
p_int: 0.999971778
p_ni: 0.000027934
p_wrong: 2.88e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
MRM2
Tbio
Family: Enzyme
Novelty: 0.06394065
p_int: 0.999963488
p_ni: 0.000036506
p_wrong: 5e-9
Data Source: BioPlex
PUSL1
Tdark
Family: Enzyme
Novelty: 2.39739964
p_int: 0.999920913
p_ni: 0.000079075
p_wrong: 1.2e-8
Data Source: BioPlex
RBM42
Tdark
Novelty: 0.37655036
p_int: 0.999899659
p_ni: 0.000100341
Data Source: BioPlex
Publication Statistics
PubMed Score  32.74

PubMed score by year
PubTator Score  9.22

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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