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Tchem
CAMK2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plast ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305762
  • ENSP00000307082
  • ENSG00000148660
  • ENST00000322635
  • ENSP00000315599
  • ENST00000351293
  • ENSP00000277853
  • ENST00000394762
  • ENSP00000378243
  • ENST00000423381
  • ENSP00000410298

Symbol
  • CAMK
  • CAMK-II
  • CAMKG
  • CAMK
  • CAMKG
  • CAMK-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
drug perturbation
0.99
molecular function
0.99
hub protein
0.95
disease perturbation
0.93


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.92   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.92   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bosutinib
chemical structure image
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
80.4
3
3
3
70.9
forced expiratory volume
1
2
2
62
self reported educational attainment
1
1
1
54.7
FEV/FEC ratio
1
2
2
49.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
80.4
3
70.9
forced expiratory volume
2
62
self reported educational attainment
1
54.7
FEV/FEC ratio
2
49.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase II gamma
VGNC:11683
738330
Macaque
calcium/calmodulin dependent protein kinase II gamma
705980
Mouse
MGI:88259
12325
Rat
RGD:621802
171140
Dog
calcium/calmodulin dependent protein kinase II gamma
VGNC:38681
489050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase II gamma
Macaque
calcium/calmodulin dependent protein kinase II gamma
Mouse
Rat
Dog
calcium/calmodulin dependent protein kinase II gamma
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13555-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (107)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 61
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ca-dependent events
Gene Ontology Terms (24)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (125)
1 – 10 of 125
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
p_int: 0.999998506
p_ni: 0.000001494
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
RBM42
Tdark
Novelty: 0.37655036
p_int: 0.999965389
p_ni: 0.000034611
Score: 0.313
Data Source: BioPlex,STRINGDB
NR3C1
Tclin
Family: NR
Novelty: 0.00029396
p_int: 0.999413412
p_ni: 0.000586588
Data Source: BioPlex
MCM5
Tbio
Novelty: 0.00716583
p_int: 0.986840187
p_ni: 0.013159814
Data Source: BioPlex
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.968105072
p_ni: 0.031894928
Score: 0.177
Data Source: BioPlex,STRINGDB
DNAL4
Tbio
Novelty: 0.15546154
p_int: 0.963389112
p_ni: 0.036610888
Data Source: BioPlex
TIRAP
Tbio
Novelty: 0.00600495
p_int: 0.895641619
p_ni: 0.104358381
Score: 0.873
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.8354114
p_ni: 0.1645886
Score: 0.477
Data Source: BioPlex,STRINGDB
ZNF488
Tdark
Novelty: 0.41027707
p_int: 0.824752974
p_ni: 0.175247026
Score: 0.313
Data Source: BioPlex,STRINGDB
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.02989472
p_int: 0.768140802
p_ni: 0.231859198
Data Source: BioPlex
Publication Statistics
PubMed Score  19.92

PubMed score by year
PubTator Score  933.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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