Tchem CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma

Protein Summary

Description

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q13555
• A0A0A0MS52
• A0A0A0MT11
• O00561
• O15378
• Q13279
• Q13282
• Q13556
• Q5SQZ3
• Q5SQZ4
• Q5SWX4
• Q7KYX5
• Q8N4I3
• Q8NIA4
• CaM kinase II subunit gamma

Gene Name

• CAMK2G

Ensembl ID

• ENST00000305762
• ENSP00000307082
• ENSG00000148660
• ENST00000322635
• ENSP00000315599
• ENST00000351293
• ENSP00000277853
• ENST00000394762
• ENSP00000378243
• ENST00000423381
• ENSP00000410298

Symbol

• CAMK
• CAMK-II
• CAMKG
• CAMK
• CAMKG
• CAMK-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
drug perturbation	0.99
molecular function	0.99
hub protein	0.95
disease perturbation	0.93

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camk2 Family / Calcium/calmodulin-dependent Protein Kinase Type Ii Subunit Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.14   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.14   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2