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Tchem
CAMK2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in res ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258682
  • ENSP00000258682
  • ENSG00000058404
  • ENST00000346990
  • ENSP00000326518
  • ENST00000347193
  • ENSP00000326544
  • ENST00000350811
  • ENSP00000326375
  • ENST00000353625
  • ENSP00000326427
  • ENST00000358707
  • ENSP00000351542
  • ENST00000395747
  • ENSP00000379096
  • ENST00000395749
  • ENSP00000379098
  • ENST00000440254
  • ENSP00000397937
  • ENST00000457475
  • ENSP00000390292

Symbol
  • CAM2
  • CAMK2
  • CAMKB
  • CAM2
  • CAMK2
  • CAMKB
  • MRD54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.94
protein domain
0.92
PubMedID
0.88
disease perturbation
0.83


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.8   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 484   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.8   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL388978
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
60.1
metabolic syndrome
1
1
1
57.4
birth weight
1
1
1
50.3
triglyceride measurement
1
1
1
38.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
60.1
metabolic syndrome
1
57.4
birth weight
1
50.3
triglyceride measurement
1
38.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
calcium/calmodulin dependent protein kinase II beta
706977
Cow
calcium/calmodulin dependent protein kinase II beta
VGNC:26722
525416
Opossum
calcium/calmodulin dependent protein kinase II beta
100024521
Anole lizard
calcium/calmodulin dependent protein kinase II beta
100554504
Xenopus
calcium/calmodulin dependent protein kinase (CaM kinase) II beta
XB-GENE-868398
780379
Species
Name
OMA
EggNOG
Inparanoid
Macaque
calcium/calmodulin dependent protein kinase II beta
Cow
calcium/calmodulin dependent protein kinase II beta
Opossum
calcium/calmodulin dependent protein kinase II beta
Anole lizard
calcium/calmodulin dependent protein kinase II beta
Xenopus
calcium/calmodulin dependent protein kinase (CaM kinase) II beta
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13554-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (110)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 61
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ca-dependent events
Gene Ontology Terms (32)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (225)
1 – 10 of 225
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
p_int: 0.999999995
p_ni: 5e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RBM42
Tdark
Novelty: 0.37655036
p_int: 0.999962216
p_ni: 0.000037784
Data Source: BioPlex
NR3C1
Tclin
Family: NR
Novelty: 0.00029396
p_int: 0.999567735
p_ni: 0.000432265
Data Source: BioPlex
DNAL4
Tbio
Novelty: 0.15546154
p_int: 0.994639542
p_ni: 0.005360458
Data Source: BioPlex
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.98264811
p_ni: 0.01735189
Data Source: BioPlex
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.976705264
p_ni: 0.023294734
p_wrong: 2e-9
Data Source: BioPlex
ZNF843
Tdark
p_int: 0.97099336
p_ni: 0.029006637
p_wrong: 3e-9
Score: 0.818
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.950128646
p_ni: 0.049871354
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.941402275
p_ni: 0.058597725
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.939015471
p_ni: 0.060984529
Score: 0.163
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  123.80

PubMed score by year
PubTator Score  50.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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