Tclin HDAC1 Histone deacetylase 1

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13547
• Q92534
• HD1

Gene Name

• HDAC1

Ensembl ID

• ENST00000373548
• ENSP00000362649
• ENSG00000116478

Symbol

• RPD3L1
• HD1
• RPD3
• KDAC1
• GON-10
• RPD3L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
hub protein	1
interacting protein	1
molecular function	1
protein complex	1

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Histone Deacetylase 1

Protein / Nucleic Acid Binding / Histone Deacetylase 1

Protein / Hydrolase / Deacetylase / Histone Deacetylase 1

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class I / Histone Deacetylase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1630.46   (req: < 5)

Gene RIFs: 421   (req: <= 3)

Antibodies: 1453   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1630.46   (req: >= 5)

Gene RIFs: 421   (req: > 3)

Antibodies: 1453   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3718

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7