Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/ ...more
- ENST00000373548
- ENSP00000362649
- ENSG00000116478
- RPD3L1
- HD1
- RPD3
- KDAC1
- GON-10
- RPD3L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
molecular function | 1 | ||
protein complex | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1472.86 (req: < 5)
Gene RIFs: 326 (req: <= 3)
Antibodies: 1453 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1472.86 (req: >= 5)
Gene RIFs: 326 (req: > 3)
Antibodies: 1453 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 58
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3326
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (3326)
Protein-Protein Interactions (878)
GATAD2B
Family: TF
Novelty: 0.056775
p_int: 0.999999999
p_ni: 1e-9
Score: 0.983
Data Source: BioPlex,STRINGDB
HMG20A
Family: TF
Novelty: 0.11994252
p_int: 0.999999998
p_ni: 2e-9
Score: 0.394
Data Source: BioPlex,STRINGDB
ZNF217
Family: TF
Novelty: 0.01313576
p_int: 0.999999993
p_ni: 4e-9
p_wrong: 4e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
HMG20B
Family: TF
Novelty: 0.05983143
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
RREB1
Family: TF
Novelty: 0.01394277
p_int: 0.999999986
p_ni: 3e-9
p_wrong: 1.1e-8
Score: 0.406
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (140)
Reactome (76)
KEGG (14)
PathwayCommons (27)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Viral Interactions (0)
Gene Ontology Terms (72)
Functions (23)
Components (14)
Processes (35)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
viral load | 1 | 1 | 1 | 66 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
viral load | 1 | 66 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | histone deacetylase 1 | 708441 | ||||||
Mouse | MGI:108086 | 433759 | ||||||
Rat | RGD:1309799 | 297893 | ||||||
Dog | histone deacetylase 1 | VGNC:50625 | 487309 | |||||
Horse | histone deacetylase 1 | VGNC:50592 | 100070281 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | histone deacetylase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone deacetylase 1 | |||||
Horse | histone deacetylase 1 | |||||
Publication Statistics
PubMed Score 1472.86
PubMed score by year
PubTator Score 1010.44
PubTator score by year
Related Publications
Text Mined References (563)
GeneRif Annotations (326)
Items per page:
0 of 0
PMID | Year | Title |
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