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Tclin
HDAC1
Histone deacetylase 1

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373548
  • ENSP00000362649
  • ENSG00000116478

Symbol
  • RPD3L1
  • HD1
  • RPD3
  • KDAC1
  • GON-10
  • RPD3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
1
interacting protein
1
molecular function
1
protein complex
1


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1406.22   (req: < 5)
Gene RIFs: 326   (req: <= 3)
Antibodies: 1453   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1406.22   (req: >= 5)
Gene RIFs: 326   (req: > 3)
Antibodies: 1453   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2451
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Active Ligands (2451)
1 – 10 of 2451
CHEMBL3622533
chemical structure image
CHEMBL99
chemical structure image
CHEMBL598797
chemical structure image
CHEMBL1631916
chemical structure image
CHEMBL1631918
chemical structure image
CHEMBL1631915
chemical structure image
CHEMBL3670668
chemical structure image
CHEMBL408513
chemical structure image
CHEMBL251011
chemical structure image
CHEMBL1631917
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
histone deacetylase 1
708441
Mouse
MGI:108086
433759
Rat
RGD:1309799
297893
Dog
histone deacetylase 1
VGNC:50625
487309
Horse
histone deacetylase 1
VGNC:50592
100070281
Species
Name
OMA
EggNOG
Inparanoid
Macaque
histone deacetylase 1
Mouse
Rat
Dog
histone deacetylase 1
Horse
histone deacetylase 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13547-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (140)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 76
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Chromatin modifying enzymes
Chromatin organization
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Gene Ontology Terms (72)
Items per page:
10
1 – 10 of 23
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (878)
1 – 10 of 878
DNTTIP1
Tbio
Family: Enzyme
Novelty: 0.1659073
p_int: 1
Score: 0.948
Data Source: BioPlex,STRINGDB
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 1
Score: 0.941
Data Source: BioPlex,STRINGDB
ELMSAN1
Tdark
Novelty: 0.65752788
p_int: 1
Score: 0.719
Data Source: BioPlex,STRINGDB
ZNF219
Tbio
Family: TF
Novelty: 0.17515242
p_int: 1
Score: 0.606
Data Source: BioPlex,STRINGDB
MIER2
Tbio
Novelty: 0.85226416
p_int: 1
Score: 0.458
Data Source: BioPlex,STRINGDB
GATAD2B
Tbio
Family: TF
Novelty: 0.056775
p_int: 0.999999999
p_ni: 1e-9
Score: 0.983
Data Source: BioPlex,STRINGDB
HMG20A
Tbio
Family: TF
Novelty: 0.11994252
p_int: 0.999999998
p_ni: 2e-9
Score: 0.394
Data Source: BioPlex,STRINGDB
ZNF217
Tbio
Family: TF
Novelty: 0.01313576
p_int: 0.999999993
p_ni: 4e-9
p_wrong: 4e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
HMG20B
Tbio
Family: TF
Novelty: 0.05983143
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
RREB1
Tbio
Family: TF
Novelty: 0.01394277
p_int: 0.999999986
p_ni: 3e-9
p_wrong: 1.1e-8
Score: 0.406
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1406.22

PubMed score by year
PubTator Score  1010.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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