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Tchem
RIPK1
Receptor-interacting serine/threonine-protein kinase 1

Protein Summary
Description
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IK ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259808
  • ENSP00000259808
  • ENSG00000137275
  • ENST00000380409
  • ENSP00000369773

Symbol
  • RIP
  • RIP1
  • RIP
  • RIP1
  • IMD57
  • RIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.99
molecular function
0.99
virus perturbation
0.98
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.13   (req: < 5)
Gene RIFs: 157   (req: <= 3)
Antibodies: 543   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.13   (req: >= 5)
Gene RIFs: 157   (req: > 3)
Antibodies: 543   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 38
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ponatinib
chemical structure image
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (126)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Cytosolic sensors of pathogen-associated DNA
Gene Ontology Terms (66)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (216)
1 – 10 of 216
NTAN1
Tbio
Family: Enzyme
Novelty: 0.00549432
p_int: 0.999999215
p_ni: 7.85e-7
Score: 0.485
Data Source: BioPlex,STRINGDB
ATG7
Tbio
Novelty: 0.00164436
p_int: 0.99993832
p_ni: 0.00006168
Score: 0.533
Data Source: BioPlex,STRINGDB
TNFRSF1A
Tchem
Novelty: 0.00048442
p_int: 0.999803553
p_ni: 0.000196447
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.02063033
p_int: 0.994999047
p_ni: 0.005000953
Score: 0.201
Data Source: BioPlex,STRINGDB
CNOT10
Tdark
Novelty: 0.50561798
p_int: 0.960174304
p_ni: 0.039825667
p_wrong: 2.9e-8
Data Source: BioPlex
THSD4
Tbio
Novelty: 0.16828393
p_int: 0.882664805
p_ni: 0.117335195
Score: 0.627
Data Source: BioPlex,STRINGDB
ABTB2
Tdark
Novelty: 3.6
p_int: 0.804825181
p_ni: 0.195166742
p_wrong: 0.000008077
Data Source: BioPlex
MLF1
Tbio
Novelty: 0.02755445
p_int: 0.754502572
p_ni: 0.245497279
p_wrong: 1.49e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.01051586
Score: 0.999
Data Source: Reactome,STRINGDB
TRADD
Tbio
Novelty: 0.00842687
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  342.13

PubMed score by year
PubTator Score  714.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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