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Tchem
RIPK1
Receptor-interacting serine/threonine-protein kinase 1

Protein Summary
Description
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IK ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259808
  • ENSP00000259808
  • ENSG00000137275
  • ENST00000380409
  • ENSP00000369773

Symbol
  • RIP
  • RIP1
  • RIP
  • RIP1
  • IMD57
  • RIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.99
molecular function
0.99
virus perturbation
0.98
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.45   (req: < 5)
Gene RIFs: 157   (req: <= 3)
Antibodies: 543   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.45   (req: >= 5)
Gene RIFs: 157   (req: > 3)
Antibodies: 543   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 146
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (216)
NTAN1
Tbio
Family:  Enzyme
Novelty:  0.01112132
p_int:  0.999999215
p_ni:  7.85e-7
Score:  0.485
Data Source:  BioPlex,STRINGDB
ATG7
Tchem
Novelty:  0.00120728
p_int:  0.99993832
p_ni:  0.00006168
Score:  0.533
Data Source:  BioPlex,STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.999803553
p_ni:  0.000196447
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.994999047
p_ni:  0.005000953
Score:  0.201
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.960174304
p_ni:  0.039825667
p_wrong:  2.9e-8
Data Source:  BioPlex
THSD4
Tbio
Novelty:  0.12898073
p_int:  0.882664805
p_ni:  0.117335195
Score:  0.627
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.804825181
p_ni:  0.195166742
p_wrong:  0.000008077
Data Source:  BioPlex
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.754502572
p_ni:  0.245497279
p_wrong:  1.49e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.999
Data Source:  Reactome,STRINGDB
TRADD
Tbio
Novelty:  0.00560091
Score:  0.999
Data Source:  Reactome,STRINGDB
Pathways (126)
Apoptosis (R-HSA-109581)

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Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Cytosolic sensors of pathogen-associated DNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (66)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
71.6
1
1
0
1.3
21.5
mean reticulocyte volume
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
71.6
0
1.3
21.5
mean reticulocyte volume
1
4.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor interacting serine/threonine kinase 1
VGNC:11209
462397
Macaque
receptor interacting serine/threonine kinase 1
708013
Mouse
MGI:108212
19766
Rat
RGD:1310158
306886
Dog
receptor interacting serine/threonine kinase 1
VGNC:45594
102152063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor interacting serine/threonine kinase 1
Macaque
receptor interacting serine/threonine kinase 1
Mouse
Rat
Dog
receptor interacting serine/threonine kinase 1
Publication Statistics
PubMed Score 588.45
PubMed score by year
PubTator Score 714.56
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title