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Tbio
EIF4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

Protein Summary
Description
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338825
  • ENSP00000340691
  • ENSG00000187840

Symbol
  • BP-1
  • 4EBP1
  • 4E-BP1
  • PHAS-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
1
transcription factor perturbation
0.98
chemical
0.97
disease perturbation
0.95
biological term
0.93


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 880.45   (req: < 5)
Gene RIFs: 148   (req: <= 3)
Antibodies: 1805   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 880.45   (req: >= 5)
Gene RIFs: 148   (req: > 3)
Antibodies: 1805   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E binding protein 1
VGNC:884
464114
Macaque
eukaryotic translation initiation factor 4E binding protein 1
703628
Mouse
MGI:103267
13685
Rat
RGD:620259
116636
Dog
eukaryotic translation initiation factor 4E binding protein 1
VGNC:40286
475590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E binding protein 1
Macaque
eukaryotic translation initiation factor 4E binding protein 1
Mouse
Rat
Dog
eukaryotic translation initiation factor 4E binding protein 1
Protein Structure (20 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13541-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (69)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Metabolism of proteins
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Metabolism of proteins
Signal Transduction
Protein-Protein Interactions (213)
1 – 10 of 213
EIF4E
Tchem
Novelty: 0.00072182
p_int: 0.99991077
p_ni: 0.000089231
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF4E2
Tbio
Novelty: 0.0490219
p_int: 0.99117197
p_ni: 0.008691013
p_wrong: 0.000137017
Score: 0.989
Data Source: BioPlex,STRINGDB
CRMP1
Tbio
Family: Enzyme
Novelty: 0.01998451
p_int: 0.972456069
p_ni: 0.027543931
Data Source: BioPlex
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
p_int: 0.860216342
p_ni: 0.139783658
Data Source: BioPlex
FBXO11
Tbio
Novelty: 0.02762674
p_int: 0.809151696
p_ni: 0.190848304
Data Source: BioPlex
RPTOR
Tbio
Novelty: 0.00119147
p_int: 0.795613003
p_ni: 0.20438463
p_wrong: 0.000002367
Score: 0.999
Data Source: BioPlex,STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.999
Data Source: Reactome,STRINGDB
MLST8
Tbio
Novelty: 0.00423122
Score: 0.997
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.996
Data Source: STRINGDB
RHEB
Tbio
Family: Enzyme
Novelty: 0.00313935
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  880.45

PubMed score by year
PubTator Score  492.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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