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Tchem
ATR
Serine/threonine-protein kinase ATR

Protein Summary
Description
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350721
  • ENSP00000343741
  • ENSG00000175054

Symbol
  • FRP1
  • FRP1
  • MEC1
  • SCKL
  • FCTCS
  • SCKL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
molecular function
0.98
chemical bioactivity profile
0.94
biological term
0.88


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.13   (req: < 5)
Gene RIFs: 319   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.13   (req: >= 5)
Gene RIFs: 319   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 112
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
5
5
98.9
mean reticulocyte volume
1
2
2
95.8
red blood cell distribution width
3
3
4
95.2
red blood cell density measurement
2
2
2
94.5
mean corpuscular hemoglobin concentration
2
2
2
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
98.9
mean reticulocyte volume
2
95.8
red blood cell distribution width
4
95.2
red blood cell density measurement
2
94.5
mean corpuscular hemoglobin concentration
2
90.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATR serine/threonine kinase
VGNC:6166
460745
Macaque
ATR serine/threonine kinase
714443
Mouse
MGI:108028
245000
Rat
RGD:1305796
685055
Dog
ATR serine/threonine kinase
VGNC:38293
100856315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATR serine/threonine kinase
Macaque
ATR serine/threonine kinase
Mouse
Rat
Dog
ATR serine/threonine kinase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13535-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
Cellular response to heat stress
Cellular responses to external stimuli
Gene Ontology Terms (32)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (496)
1 – 10 of 496
PDGFRB
Tclin
Family:  Kinase
Novelty:  0.00074896
p_int:  0.999990954
p_ni:  0.000009046
Score:  0.287
Data Source:  BioPlex,STRINGDB
CD274
Tclin
Novelty:  0.00013449
p_int:  0.999980106
p_ni:  0.000019894
Score:  0.155
Data Source:  BioPlex,STRINGDB
GYPA
Tbio
Novelty:  0.00067203
p_int:  0.999972958
p_ni:  0.000027042
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.999954521
p_ni:  0.000045479
Data Source:  BioPlex
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.999950956
p_ni:  0.000049044
Data Source:  BioPlex
CA14
Tclin
Family:  Enzyme
Novelty:  0.00864764
p_int:  0.999908108
p_ni:  0.000091892
Data Source:  BioPlex
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.999906484
p_ni:  0.000093516
Score:  0.199
Data Source:  BioPlex,STRINGDB
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.999879645
p_ni:  0.000120355
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.999867212
p_ni:  0.000132788
Data Source:  BioPlex
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.999681409
p_ni:  0.000318591
Data Source:  BioPlex
Publication Statistics
PubMed Score  424.13

PubMed score by year
PubTator Score  1277.69

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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