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Tbio
SERINC3
Serine incorporator 3

Protein Summary
Description
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255175
  • ENSP00000255175
  • ENSG00000132824
  • ENST00000342374
  • ENSP00000340243

Symbol
  • DIFF33
  • TDE1
  • TDE
  • TDE1
  • AIGP1
  • TMS-1
  • DIFF33
  • SBBI99
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
virus perturbation
0.99
disease perturbation
0.98
cell type or tissue
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.79   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.79   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine incorporator 3
VGNC:6262
469950
Macaque
serine incorporator 3
712545
Mouse
MGI:1349457
26943
Rat
RGD:1308390
296350
Dog
serine incorporator 3
VGNC:46021
477235
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine incorporator 3
Macaque
serine incorporator 3
Mouse
Rat
Dog
serine incorporator 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13530-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Serine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Serine biosynthesis
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (20)
1 – 10 of 20
GRXCR1
Tdark
Novelty: 0.17455124
Score: 0.905
Data Source: STRINGDB
CLGN
Tbio
Novelty: 0.06204915
Score: 0.716
Data Source: STRINGDB
DDT
Tbio
Family: Enzyme
Novelty: 0.02510903
Score: 0.7
Data Source: STRINGDB
IBTK
Tbio
Family: Enzyme
Novelty: 0.03448246
Score: 0.584
Data Source: STRINGDB
GLRX
Tbio
Novelty: 0.00111903
Score: 0.533
Data Source: STRINGDB
ADAM2
Tbio
Family: Enzyme
Novelty: 0.00586482
Score: 0.527
Data Source: STRINGDB
SAMD14
Tbio
Novelty: 0.19225592
Score: 0.513
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.511
Data Source: STRINGDB
SAMHD1
Tbio
Family: Enzyme
Novelty: 0.00294595
Score: 0.499
Data Source: STRINGDB
BST2
Tbio
Novelty: 0.00254359
Score: 0.491
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.79

PubMed score by year
PubTator Score  27.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer