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Tchem
PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Protein Summary
Description
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, Ref. 21). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dime ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247970
  • ENSP00000247970
  • ENSG00000127445
  • ENST00000588695
  • ENSP00000466962

Symbol
  • DOD
  • UBL5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
0.98
biological term
0.9
disease perturbation
0.87
kinase
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.02   (req: < 5)
Gene RIFs: 311   (req: <= 3)
Antibodies: 683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.02   (req: >= 5)
Gene RIFs: 311   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
81.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
81.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
745021
Macaque
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
711095
Mouse
MGI:1346036
23988
Rat
RGD:1310299
298696
Dog
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
484963
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Macaque
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Mouse
Rat
Dog
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Protein Structure (79 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13526-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 79
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (46)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Protein-Protein Interactions (201)
1 – 10 of 201
ETV6
Tbio
Family: TF
Novelty: 0.00151718
p_int: 0.999720831
p_ni: 0.000012047
p_wrong: 0.000267121
Score: 0.188
Data Source: BioPlex,STRINGDB
C2orf49
Tbio
Novelty: 0.03911934
p_int: 0.999688701
p_ni: 0.000310069
p_wrong: 0.000001231
Data Source: BioPlex
SUPT6H
Tbio
Novelty: 0.01099565
p_int: 0.998828692
p_ni: 0.001171308
Score: 0.376
Data Source: BioPlex,STRINGDB
DIDO1
Tbio
Family: Epigenetic
Novelty: 0.0492858
p_int: 0.997548439
p_ni: 0.002451527
p_wrong: 3.4e-8
Score: 0.512
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.995261309
p_ni: 0.004731475
p_wrong: 0.000007216
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.967454934
p_ni: 0.032545066
p_wrong: 1e-9
Score: 0.272
Data Source: BioPlex,STRINGDB
RPRD1B
Tbio
Novelty: 0.0444394
p_int: 0.962105645
p_ni: 0.037893543
p_wrong: 8.12e-7
Score: 0.274
Data Source: BioPlex,STRINGDB
POLR2D
Tdark
Family: Enzyme
Novelty: 0.11021614
p_int: 0.918750857
p_ni: 0.081249083
p_wrong: 6e-8
Score: 0.232
Data Source: BioPlex,STRINGDB
TUT1
Tbio
Family: Enzyme
Novelty: 0.01436913
p_int: 0.902714515
p_ni: 0.062484209
p_wrong: 0.034801276
Score: 0.185
Data Source: BioPlex,STRINGDB
PIN1P1
Tdark
p_int: 0.866332607
p_wrong: 0.133667393
Data Source: BioPlex
Publication Statistics
PubMed Score  113.02

PubMed score by year
PubTator Score  599.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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