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Tchem
PRPF4B
Serine/threonine-protein kinase PRP4 homolog

Protein Summary
Description
Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337659
  • ENSP00000337194
  • ENSG00000112739
  • ENST00000480058
  • ENSP00000433547

Symbol
  • KIAA0536
  • PRP4
  • PRP4H
  • PRP4K
  • PR4H
  • PRP4
  • PRP4H
  • PRP4K
  • dJ1013A10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase
0.98
hub protein
0.97
molecular function
0.95
virus perturbation
0.95


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 4B
VGNC:3672
462406
Macaque
pre-mRNA processing factor 4B
709497
Mouse
MGI:109584
19134
Rat
RGD:1307784
291078
Dog
pre-mRNA processing factor 4B
VGNC:45028
488199
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 4B
Macaque
pre-mRNA processing factor 4B
Mouse
Rat
Dog
pre-mRNA processing factor 4B
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13523-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (119)
1 – 10 of 119
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.998740207
p_ni: 0.001259772
p_wrong: 2e-8
Data Source: BioPlex
PNN
Tbio
Novelty: 0.01395394
p_int: 0.988491405
p_ni: 0.011508595
Score: 0.948
Data Source: BioPlex,STRINGDB
SAP18
Tbio
Family: Enzyme
Novelty: 0.03918373
p_int: 0.966644124
p_ni: 0.033355876
Data Source: BioPlex
HIST1H1T
Tdark
Novelty: 0.01039464
p_int: 0.903292887
p_ni: 0.096707113
Data Source: BioPlex
RPS14
Tbio
Novelty: 0.00576737
p_int: 0.893017094
p_ni: 0.106982906
Data Source: BioPlex
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.879169077
p_ni: 0.120830923
Score: 0.368
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.874818351
p_ni: 0.125181648
p_wrong: 1e-9
Score: 0.356
Data Source: BioPlex,STRINGDB
ZNF2
Tbio
Family: TF
Novelty: 0.01062543
p_int: 0.85599278
p_ni: 0.144007219
Score: 0.164
Data Source: BioPlex,STRINGDB
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.795489499
p_ni: 0.204494267
p_wrong: 0.000016234
Score: 0.151
Data Source: BioPlex,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.791163849
p_ni: 0.20883615
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  20.59

PubMed score by year
PubTator Score  19.75

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer