Tchem PRPF4B Serine/threonine-protein kinase PRP4 homolog

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Serine/threonine-protein Kinase Prp4 Homolog

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase Prp4 Homolog

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Dyrk Family / Serine/threonine-protein Kinase Prp4 Homolog

Protein Summary

Description

Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13523
• A8K5C9
• Q5D0F6
• Q5TAY8
• Q8IVC3
• Q8TDP2
• Q96QT7
• Q9UEE6

Gene Name

• PRPF4B

Ensembl ID

• ENST00000337659
• ENSP00000337194
• ENSG00000112739
• ENST00000480058
• ENSP00000433547

Symbol

• KIAA0536
• PRP4
• PRP4H
• PRP4K
• PR4H
• PRP4
• PRP4H
• PRP4K
• dJ1013A10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
kinase	0.98
hub protein	0.97
molecular function	0.95
virus perturbation	0.95

Related Tools

Dark Kinase Knowledgebase

The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.

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ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

nintedanib

PRPF4BTchem Kinase

Kd : 8.08

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pre-mRNA processing factor 4B	VGNC:3672	462406
Macaque	pre-mRNA processing factor 4B		709497
Mouse	pre-mRNA processing factor 4B	MGI:109584	19134
Rat	pre-mRNA processing factor 4B	RGD:1307784	291078
Dog	pre-mRNA processing factor 4B	VGNC:45028	488199

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pre-mRNA processing factor 4B
Macaque	pre-mRNA processing factor 4B
Mouse	pre-mRNA processing factor 4B
Rat	pre-mRNA processing factor 4B
Dog	pre-mRNA processing factor 4B

Protein Structure (5 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13523-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (3)

PathwayCommons (2)

WikiPathways (1)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	EGFR1	472 targets	PathwayCommons: netpath
PathwayCommons: netpath	TCR	258 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
EGFR1	472 targets	PathwayCommons: netpath
TCR	258 targets	PathwayCommons: netpath

Gene Ontology Terms (11)

Functions (4)

Components (4)

Processes (3)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
protein kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein serine/threonine kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (119)

Explore Interacting Targets

1 – 10 of 119

• See Interactions on String-DB

ZC3H18

Tdark

Novelty: 0.3515546

p_int: 0.998740207

p_ni: 0.001259772

p_wrong: 2e-8

Data Source: BioPlex

PNN

Tbio

Novelty: 0.01395394

p_int: 0.988491405

p_ni: 0.011508595

Score: 0.948

Data Source: BioPlex,STRINGDB

SAP18

Tbio

Family: Enzyme

Novelty: 0.03918373

p_int: 0.966644124

p_ni: 0.033355876

Data Source: BioPlex

HIST1H1T

Tdark

Novelty: 0.01039464

p_int: 0.903292887

p_ni: 0.096707113

Data Source: BioPlex

RPS14

Tbio

Novelty: 0.00576737

p_int: 0.893017094

p_ni: 0.106982906

Data Source: BioPlex

RBM34

Tdark

Novelty: 0.58131282

p_int: 0.879169077

p_ni: 0.120830923

Score: 0.368

Data Source: BioPlex,STRINGDB

NKAPD1

Tdark

Novelty: 1.56979675

p_int: 0.874818351

p_ni: 0.125181648

p_wrong: 1e-9

Score: 0.356

Data Source: BioPlex,STRINGDB

ZNF2

Tbio

Family: TF

Novelty: 0.01062543

p_int: 0.85599278

p_ni: 0.144007219

Score: 0.164

Data Source: BioPlex,STRINGDB

H2AFY2

Tbio

Novelty: 0.09948698

p_int: 0.795489499

p_ni: 0.204494267

p_wrong: 0.000016234

Score: 0.151

Data Source: BioPlex,STRINGDB

HDGFL2

Tbio

Family: Epigenetic

Novelty: 0.11846257

p_int: 0.791163849

p_ni: 0.20883615

p_wrong: 2e-9

Data Source: BioPlex

Publication Statistics

PubMed Score  20.59

PubMed score by year

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PubTator Score  19.75

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
ATP-binding
Complete proteome
Isopeptide bond
Kinase
mRNA processing
mRNA splicing
Nucleotide-binding
Nucleus

MGI Phenotype Find Similar Targets

mortality/aging