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Tchem
PRPF4B
Serine/threonine-protein kinase PRP4 homolog

Protein Summary
Description
Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337659
  • ENSP00000337194
  • ENSG00000112739
  • ENST00000480058
  • ENSP00000433547

Symbol
  • KIAA0536
  • PRP4
  • PRP4H
  • PRP4K
  • PR4H
  • PRP4
  • PRP4H
  • PRP4K
  • dJ1013A10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase
0.98
hub protein
0.97
molecular function
0.95
virus perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.33   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.33   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1