PRPF4B
Serine/threonine-protein kinase PRP4 homolog
Protein Summary
Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
- ENST00000337659
- ENSP00000337194
- ENSG00000112739
- ENST00000480058
- ENSP00000433547
- KIAA0536
- PRP4
- PRP4H
- PRP4K
- PR4H
- PRP4
- PRP4H
- PRP4K
- dJ1013A10.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.98 | ||
kinase | 0.98 | ||
hub protein | 0.97 | ||
molecular function | 0.95 | ||
virus perturbation | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.34 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.34 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (119)
ZC3H18
Novelty: 0.3515546
p_int: 0.998740207
p_ni: 0.001259772
p_wrong: 2e-8
Data Source: BioPlex
PNN
Novelty: 0.01395394
p_int: 0.988491405
p_ni: 0.011508595
Score: 0.948
Data Source: BioPlex,STRINGDB
SAP18
Family: Enzyme
Novelty: 0.03918373
p_int: 0.966644124
p_ni: 0.033355876
Data Source: BioPlex
RBM34
Novelty: 0.58131282
p_int: 0.879169077
p_ni: 0.120830923
Score: 0.368
Data Source: BioPlex,STRINGDB
NKAPD1
Novelty: 1.56979675
p_int: 0.874818351
p_ni: 0.125181648
p_wrong: 1e-9
Score: 0.356
Data Source: BioPlex,STRINGDB
ZNF2
Family: TF
Novelty: 0.01062543
p_int: 0.85599278
p_ni: 0.144007219
Score: 0.164
Data Source: BioPlex,STRINGDB
H2AFY2
Novelty: 0.09948698
p_int: 0.795489499
p_ni: 0.204494267
p_wrong: 0.000016234
Score: 0.151
Data Source: BioPlex,STRINGDB
HDGFL2
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.791163849
p_ni: 0.20883615
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
PathwayCommons (2)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: netpath | EGFR1 | ||||
PathwayCommons: netpath | TCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
EGFR1 | ||||
TCR | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood metabolite measurement | 1 | 1 | 1 | 82 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood metabolite measurement | 1 | 82 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pre-mRNA processing factor 4B | VGNC:3672 | 462406 | |||||
Macaque | pre-mRNA processing factor 4B | 709497 | ||||||
Mouse | MGI:109584 | 19134 | ||||||
Rat | RGD:1307784 | 291078 | ||||||
Dog | pre-mRNA processing factor 4B | VGNC:45028 | 488199 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pre-mRNA processing factor 4B | |||||
Macaque | pre-mRNA processing factor 4B | |||||
Mouse | ||||||
Rat | ||||||
Dog | pre-mRNA processing factor 4B | |||||
Publication Statistics
PubMed Score 21.34
PubMed score by year
PubTator Score 19.75
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (34)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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