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Tbio
AQP6
Aquaporin-6

Protein Summary
Description
Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315520
  • ENSP00000320247
  • ENSG00000086159
  • ENST00000615425
  • ENSP00000477688

Symbol
  • AQP2L
  • KID
  • AQP2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.83
molecular function
0.79
kinase perturbation
0.66
protein domain
0.58
cell line
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.86   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.86   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
AQP10
Tbio
Novelty:  0.03507619
Score:  0.906
Data Source:  STRINGDB
AQP12A
Tbio
Novelty:  0.04258853
Score:  0.867
Data Source:  STRINGDB
AQP11
Tbio
Novelty:  0.0229197
Score:  0.844
Data Source:  STRINGDB
MTF2
Tbio
Family:  Epigenetic
Novelty:  0.01152147
Score:  0.656
Data Source:  STRINGDB
NECTIN3
Tbio
Novelty:  0.01288113
Score:  0.645
Data Source:  STRINGDB
RHBG
Tbio
Novelty:  0.01752773
Score:  0.52
Data Source:  STRINGDB
RHAG
Tbio
Novelty:  0.00094983
Score:  0.514
Data Source:  STRINGDB
RHCG
Tbio
Novelty:  0.00506312
Score:  0.491
Data Source:  STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.488
Data Source:  STRINGDB
AQP3
Tchem
Novelty:  0.00177269
Score:  0.443
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
93.8
comparative body size at age 10, self-reported
1
1
1
87.3
body height
1
1
1
82.4
obese body mass index status
2
1
0
1.2
80.3
visceral adipose tissue measurement
1
1
1
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
93.8
comparative body size at age 10, self-reported
1
87.3
body height
1
82.4
obese body mass index status
0
1.2
80.3
visceral adipose tissue measurement
1
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquaporin 6
VGNC:4930
741338
Mouse
MGI:1341204
11831
Rat
RGD:71100
29170
Dog
aquaporin 6
VGNC:38019
607978
Horse
aquaporin 6
VGNC:15434
100629869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquaporin 6
Mouse
Rat
Dog
aquaporin 6
Horse
aquaporin 6
Publication Statistics
PubMed Score 40.86
PubMed score by year
PubTator Score 23.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title