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Tbio
PNOC
Prepronociceptin

Protein Summary
Description
Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. Orphanin FQ2: Has potent analgesic activity. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301908
  • ENSP00000301908
  • ENSG00000168081
  • ENST00000522209
  • ENSP00000430145

Symbol
  • OFQ
  • NOP
  • OFQ
  • N/OFQ
  • PPNOC
  • ppN/OFQ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
disease
0.52
PubMedID
0.51
chemical
0.5
pathway
0.47


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1052.12   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1052.12   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prepronociceptin
VGNC:820
464083
Macaque
prepronociceptin
713633
Mouse
MGI:105308
18155
Rat
RGD:3362
25516
Dog
prepronociceptin
VGNC:44750
486095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prepronociceptin
Macaque
prepronociceptin
Mouse
Rat
Dog
prepronociceptin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13519-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (281)
1 – 10 of 281
WDFY2
Tbio
Novelty: 0.01835759
p_int: 0.99999949
p_ni: 4.46e-7
p_wrong: 6.4e-8
Data Source: BioPlex
NUP155
Tbio
Novelty: 0.03884486
p_int: 0.99998099
p_ni: 0.00001901
Data Source: BioPlex
CDC26
Tbio
Family: Enzyme
Novelty: 0.07456358
p_int: 0.99995238
p_ni: 0.000029475
p_wrong: 0.000018145
Data Source: BioPlex
PDP1
Tbio
Family: Enzyme
Novelty: 0.00442352
p_int: 0.998133718
p_ni: 0.001866263
p_wrong: 1.9e-8
Data Source: BioPlex
CETN3
Tbio
Novelty: 0.00705513
p_int: 0.998095252
p_ni: 0.001904748
Data Source: BioPlex
WDTC1
Tbio
Novelty: 0.02300849
p_int: 0.993564426
p_ni: 0.006435573
Data Source: BioPlex
ABRAXAS2
Tbio
Novelty: 0.20430604
p_int: 0.989330431
p_ni: 0.010669568
p_wrong: 1e-9
Data Source: BioPlex
BABAM1
Tbio
Novelty: 0.03812501
p_int: 0.960773926
p_ni: 0.038208341
p_wrong: 0.001017734
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.945574214
p_ni: 0.054425786
Data Source: BioPlex
TIMM10B
Tdark
Family: Enzyme
Novelty: 0.36798313
p_int: 0.934621629
p_ni: 0.001700624
p_wrong: 0.063677747
Data Source: BioPlex
Publication Statistics
PubMed Score  1052.12

PubMed score by year
PubTator Score  451.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer