You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ASAH1
Acid ceramidase

Protein Summary
Description
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262097
  • ENSP00000262097
  • ENSG00000104763
  • ENST00000314146
  • ENSP00000326970
  • ENST00000381733
  • ENSP00000371152
  • ENST00000635998
  • ENSP00000490506
  • ENST00000637790
  • ENSP00000490272

Symbol
  • ASAH
  • AC
  • PHP
  • ASAH
  • PHP32
  • ACDase
  • SMAPME
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.98
transcription factor perturbation
0.98
kinase perturbation
0.97
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.96   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.96   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 106
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
carmofur
Rendered image for carmofur
Active Ligands (106)
1 – 10 of 106
CHEMBL4451058
Rendered image for CHEMBL4451058
CHEMBL3770896
Rendered image for CHEMBL3770896
CHEMBL4100592
Rendered image for CHEMBL4100592
CHEMBL429926
Rendered image for CHEMBL429926
CHEMBL3741996
Rendered image for CHEMBL3741996
Protein-Protein Interactions (150)
1 – 10 of 150
AAGAB
Tbio
Novelty:  0.0479209
p_int:  0.999959399
p_ni:  0.000040601
Data Source:  BioPlex
AAMP
Tbio
Novelty:  0.0160792
p_int:  0.999340787
p_ni:  0.000638277
p_wrong:  0.000020936
Score:  0.193
Data Source:  BioPlex,STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
p_int:  0.999328011
p_ni:  0.000671989
Score:  0.198
Data Source:  BioPlex,STRINGDB
GLT1D1
Tdark
Family:  Enzyme
Novelty:  0.33685691
p_int:  0.98147062
p_ni:  0.01852938
Score:  0.237
Data Source:  BioPlex,STRINGDB
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.970874316
p_ni:  0.029125664
p_wrong:  2e-8
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.943582339
p_ni:  0.056417661
Data Source:  BioPlex
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.939076972
p_ni:  0.060923028
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.923362534
p_ni:  0.076634272
p_wrong:  0.000003194
Score:  0.912
Data Source:  BioPlex,STRINGDB
NONO
Tbio
Novelty:  0.00501502
p_int:  0.90328923
p_ni:  0.09671077
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.902765446
p_ni:  0.097234554
Data Source:  BioPlex
Pathways (111)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.1
73.9
triglyceride measurement
1
1
1
38.8
1
1
0
1.1
33.1
mean reticulocyte volume
1
1
1
31.4
self reported educational attainment
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
73.9
triglyceride measurement
1
38.8
0
1.1
33.1
mean reticulocyte volume
1
31.4
self reported educational attainment
1
24.5
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acylsphingosine amidohydrolase 1
VGNC:53738
464022
Macaque
N-acylsphingosine amidohydrolase 1
703699
Mouse
MGI:1277124
11886
Rat
RGD:621568
84431
Dog
N-acylsphingosine amidohydrolase 1
VGNC:38152
482897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acylsphingosine amidohydrolase 1
Macaque
N-acylsphingosine amidohydrolase 1
Mouse
Rat
Dog
N-acylsphingosine amidohydrolase 1
Publication Statistics
PubMed Score 288.96
PubMed score by year
PubTator Score 168.93
PubTator score by year