TUBB3
Tubulin beta-3 chain
Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
- ENST00000315491
- ENSP00000320295
- ENSG00000258947
- ENST00000554444
- ENSP00000451617
- TUBB4
- CDCBM
- FEOM3
- TUBB4
- CDCBM1
- CFEOM3
- beta-4
- CFEOM3A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
protein complex | 1 | ||
protein domain | 0.97 | ||
molecular function | 0.96 | ||
PubMedID | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 353.12 (req: < 5)
Gene RIFs: 140 (req: <= 3)
Antibodies: 942 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 353.12 (req: >= 5)
Gene RIFs: 140 (req: > 3)
Antibodies: 942 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13