Tclin TUBB3 Tubulin beta-3 chain

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta-3 Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta-3 Chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q13509
• A8K854
• Q9BTZ0
• Q9BW10

Gene Name

• TUBB3

Ensembl ID

• ENST00000315491
• ENSP00000320295
• ENSG00000258947
• ENST00000554444
• ENSP00000451617

Symbol

• TUBB4
• CDCBM
• FEOM3
• TUBB4
• CDCBM1
• CFEOM3
• beta-4
• CFEOM3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein complex	1
protein domain	0.97
molecular function	0.96
PubMedID	0.95

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.23   (req: < 5)

Gene RIFs: 115   (req: <= 3)

Antibodies: 942   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.23   (req: >= 5)

Gene RIFs: 115   (req: > 3)

Antibodies: 942   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13

Approved Drugs (13)

Explore Approved Drugs

1 – 10 of 13

docetaxel

TUBB3Tclin

INHIBITOR ID50 : 6.69899988

trastuzumab emtansine

TUBB3Tclin

INHIBITOR :

paclitaxel

TUBB3Tclin

INHIBITOR EC50 : 8.05

brentuximab vedotin

TUBB3Tclin

INHIBITOR :

vinblastine

TUBB3Tclin

INHIBITOR IC50 : 9

vinorelbine

TUBB3Tclin

INHIBITOR :

polatuzumab vedotin

TUBB3Tclin

BINDING AGENT :

enfortumab vedotin

TUBB3Tclin

BINDING AGENT :

eribulin

TUBB3Tclin

INHIBITOR IC50 : 8.22999954

vincristine

TUBB3Tclin

INHIBITOR :

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

CHEMBL67

TUBB3Tclin

IC50 : 8.28

CHEMBL2391703

TUBB3Tclin

IC50 : 7.34

CHEMBL1824506

TUBB3Tclin

IC50 : 7.62

CHEMBL2391709

TUBB3Tclin

IC50 : 7.67

CHEMBL2391704

TUBB3Tclin

IC50 : 7.73

CHEMBL2425924

TUBB3Tclin

IC50 : 8.09

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hair color	EFO_0003924	1	2	0	2.6	91.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hair color	EFO_0003924	0	2.6	91.2

Reset Zoom  Beta Count   Odds Ratio

Protein Structure (4 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13509-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (17)

Reactome (9)

KEGG (3)

PathwayCommons (2)

WikiPathways (3)

Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

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Find Similar Targets

Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Reactome	Formation of tubulin folding intermediates by CCT/TriC	26 targets	R-HSA-389960
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Formation of tubulin folding intermediates by CCT/TriC	26 targets	R-HSA-389960
Metabolism of proteins	2050 targets	R-HSA-392499

Gene Ontology Terms (14)

Functions (3)

Components (6)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
GTP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of cytoskeleton	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (290)

Explore Interacting Targets

1 – 10 of 290

• See Interactions on String-DB

DLGAP5

Tbio

Novelty: 0.01673312

p_int: 0.999999999

p_ni: 1e-9

Data Source: BioPlex

EML6

Tdark

Novelty: 0.40631576

p_int: 0.999999511

p_ni: 1.96e-7

p_wrong: 2.93e-7

Score: 0.326

Data Source: BioPlex,STRINGDB

TUBB1

Tclin

Novelty: 0.02806117

p_int: 0.999996093

p_ni: 0.000003907

Score: 0.207

Data Source: BioPlex,STRINGDB

EML2

Tbio

Novelty: 0.09538181

p_int: 0.999995361

p_ni: 0.000004639

Score: 0.552

Data Source: BioPlex,STRINGDB

CAPS

Tbio

Novelty: 0.04549022

p_int: 0.998928795

p_ni: 0.001071205

Data Source: BioPlex

EML1

Tbio

Novelty: 0.02262549

p_int: 0.998123451

p_ni: 0.00176902

p_wrong: 0.000107529

Score: 0.552

Data Source: BioPlex,STRINGDB

OSTM1

Tbio

Novelty: 0.03033192

p_int: 0.997128041

p_ni: 0.002871959

Data Source: BioPlex

TPSB2

Tbio

Family: Enzyme

Novelty: 0.00757397

p_int: 0.996523879

p_ni: 0.003476121

Data Source: BioPlex

TUBB

Tclin

Novelty: 0.0038007

p_int: 0.995895241

p_ni: 0.004104759

Score: 0.2

Data Source: BioPlex,STRINGDB

LRP1

Tbio

Novelty: 0.00200788

p_int: 0.989750293

p_ni: 0.010249707

Data Source: BioPlex

Publication Statistics

PubMed Score  302.23

PubMed score by year

Reset Zoom

PubTator Score  553.03

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Microtubule

GWAS Trait Find Similar Targets

hair color

MGI Phenotype Find Similar Targets

cellular phenotype
mortality/aging
nervous system phenotype
respiratory system phenotype