Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
- ENST00000315491
- ENSP00000320295
- ENSG00000258947
- ENST00000554444
- ENSP00000451617
- TUBB4
- CDCBM
- FEOM3
- TUBB4
- CDCBM1
- CFEOM3
- beta-4
- CFEOM3A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
protein complex | 1 | ||
protein domain | 0.97 | ||
molecular function | 0.96 | ||
PubMedID | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 310.78 (req: < 5)
Gene RIFs: 115 (req: <= 3)
Antibodies: 942 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 310.78 (req: >= 5)
Gene RIFs: 115 (req: > 3)
Antibodies: 942 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
Active Ligands (6)
Protein-Protein Interactions (290)
EML6
Novelty: 0.40631576
p_int: 0.999999511
p_ni: 1.96e-7
p_wrong: 2.93e-7
Score: 0.326
Data Source: BioPlex,STRINGDB
TUBB1
Novelty: 0.02806117
p_int: 0.999996093
p_ni: 0.000003907
Score: 0.207
Data Source: BioPlex,STRINGDB
EML2
Novelty: 0.09538181
p_int: 0.999995361
p_ni: 0.000004639
Score: 0.552
Data Source: BioPlex,STRINGDB
EML1
Novelty: 0.02262549
p_int: 0.998123451
p_ni: 0.00176902
p_wrong: 0.000107529
Score: 0.552
Data Source: BioPlex,STRINGDB
TPSB2
Family: Enzyme
Novelty: 0.00757397
p_int: 0.996523879
p_ni: 0.003476121
Data Source: BioPlex
TUBB
Novelty: 0.0038007
p_int: 0.995895241
p_ni: 0.004104759
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (17)
Reactome (9)
KEGG (3)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Carboxyterminal post-translational modifications of tubulin | ||||
Reactome | Chaperonin-mediated protein folding | ||||
Reactome | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||||
Reactome | Formation of tubulin folding intermediates by CCT/TriC | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Carboxyterminal post-translational modifications of tubulin | ||||
Chaperonin-mediated protein folding | ||||
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||||
Formation of tubulin folding intermediates by CCT/TriC | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hair color | 9 | 29 | 1 | 2.3 | 99.9 | ||||
suntan | 3 | 8 | 8 | 99.7 | |||||
2 | 4 | 0 | 1.3 | 98.6 | |||||
4 | 3 | 2 | 1.4 | 97.5 | |||||
3 | 3 | 0 | 1.3 | 96.2 | |||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hair color | 1 | 2.3 | 99.9 | ||||
suntan | 8 | 99.7 | |||||
0 | 1.3 | 98.6 | |||||
2 | 1.4 | 97.5 | |||||
0 | 1.3 | 96.2 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 310.78
PubMed score by year
PubTator Score 553.03
PubTator score by year
Related Publications
Text Mined References (138)
GeneRif Annotations (115)
Items per page:
0 of 0
PMID | Year | Title |
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