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Tclin
TUBB3
Tubulin beta-3 chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315491
  • ENSP00000320295
  • ENSG00000258947
  • ENST00000554444
  • ENSP00000451617

Symbol
  • TUBB4
  • CDCBM
  • FEOM3
  • TUBB4
  • CDCBM1
  • CFEOM3
  • beta-4
  • CFEOM3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
protein domain
0.97
molecular function
0.96
PubMedID
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.23   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 942   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.23   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 942   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2
0
2.6
91.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
2.6
91.2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (290)
1 – 10 of 290
DLGAP5
Tbio
Novelty: 0.01673312
p_int: 0.999999999
p_ni: 1e-9
Data Source: BioPlex
EML6
Tdark
Novelty: 0.40631576
p_int: 0.999999511
p_ni: 1.96e-7
p_wrong: 2.93e-7
Score: 0.326
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999996093
p_ni: 0.000003907
Score: 0.207
Data Source: BioPlex,STRINGDB
EML2
Tbio
Novelty: 0.09538181
p_int: 0.999995361
p_ni: 0.000004639
Score: 0.552
Data Source: BioPlex,STRINGDB
CAPS
Tbio
Novelty: 0.04549022
p_int: 0.998928795
p_ni: 0.001071205
Data Source: BioPlex
EML1
Tbio
Novelty: 0.02262549
p_int: 0.998123451
p_ni: 0.00176902
p_wrong: 0.000107529
Score: 0.552
Data Source: BioPlex,STRINGDB
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.997128041
p_ni: 0.002871959
Data Source: BioPlex
TPSB2
Tbio
Family: Enzyme
Novelty: 0.00757397
p_int: 0.996523879
p_ni: 0.003476121
Data Source: BioPlex
TUBB
Tclin
Novelty: 0.0038007
p_int: 0.995895241
p_ni: 0.004104759
Score: 0.2
Data Source: BioPlex,STRINGDB
LRP1
Tbio
Novelty: 0.00200788
p_int: 0.989750293
p_ni: 0.010249707
Data Source: BioPlex
Publication Statistics
PubMed Score  302.23

PubMed score by year
PubTator Score  553.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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