Tbio ART3 Ecto-ADP-ribosyltransferase 3

Protein Summary

Description

This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q13508
• Q53XW3
• Q6FHT7
• Q8WVJ7
• Q93069
• Q96HL1

Gene Name

• ART3

Ensembl ID

• ENST00000341029
• ENSP00000343843
• ENSG00000156219
• ENST00000349321
• ENSP00000304313
• ENST00000355810
• ENSP00000348064

Symbol

• TMART
• ARTC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
gene perturbation	0.8
disease perturbation	0.62
co-expressed gene	0.57
disease	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.38   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 356   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.38   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (94)

Explore Interacting Targets

1 – 10 of 94

• See Interactions on String-DB

CBWD3

Tdark

Novelty:  0.03639787

p_int:  0.996256748

p_ni:  0.003743209

p_wrong:  4.3e-8

Score:  0.245

Data Source:  BioPlex,STRINGDB

ATP12A

Tchem

Family:  Transporter

Novelty:  0.00008793

p_int:  0.984380962

p_ni:  0.015619035

p_wrong:  3e-9

Score:  0.152

Data Source:  BioPlex,STRINGDB

ITGA8

Tbio

Novelty:  0.0220023

p_int:  0.950744602

p_ni:  0.042805207

p_wrong:  0.006450191

Data Source:  BioPlex

ARSK

Tbio

Family:  Enzyme

Novelty:  0.11486213

p_int:  0.914626837

p_ni:  0.085373163

Score:  0.191

Data Source:  BioPlex,STRINGDB

NAGLU

Tbio

Family:  Enzyme

Novelty:  0.01033079

p_int:  0.827343871

p_ni:  0.172656129

Score:  0.177

Data Source:  BioPlex,STRINGDB

POGLUT1

Tbio

Family:  Enzyme

Novelty:  0.03821516

p_int:  0.821146282

p_ni:  0.178853695

p_wrong:  2.3e-8

Score:  0.183

Data Source:  BioPlex,STRINGDB

HSPA12A

Tbio

Novelty:  0.11999085

p_int:  0.808699894

p_ni:  0.191300105

Score:  0.22

Data Source:  BioPlex,STRINGDB

PAM

Tchem

Family:  Enzyme

Novelty:  0.00378397

p_int:  0.759011932

p_ni:  0.240988048

p_wrong:  2e-8

Score:  0.188

Data Source:  BioPlex,STRINGDB

ART4

Tbio

Family:  Enzyme

Novelty:  0.15332159

Score:  0.93

Data Source:  STRINGDB

CD109

Tbio

Novelty:  0.01280272

Score:  0.923

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Metabolism of proteins (R-HSA-392499)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (2)

Components (5)

Processes (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
NAD+ ADP-ribosyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
NAD(P)+-protein-arginine ADP-ribosyltransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (7)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-X-C motif chemokine 10 measurement	EFO_0008056	2	2	0	1.7	91.4
body mass index	EFO_0004340	3	2	4		64.8
fetal genotype effect measurement	EFO_0007959	1	1	1		61.4
protein measurement	EFO_0004747	1	1	1		61.4
monokine induced by gamma interferon measurement	EFO_0008236	1	2	2		57.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-X-C motif chemokine 10 measurement	EFO_0008056	0	1.7	91.4
body mass index	EFO_0004340	4		64.8
fetal genotype effect measurement	EFO_0007959	1		61.4
protein measurement	EFO_0004747	1		61.4
monokine induced by gamma interferon measurement	EFO_0008236	2		57.7

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Glycosyltransferase
GPI-anchor
Lipoprotein
Membrane
NAD

GWAS Trait Find Similar Targets

No Header	No Header
age at first birth measurement
body mass index
C-X-C motif chemokine 10 measurement
fetal genotype effect measurement
monokine induced by gamma interferon measurement
protein measurement
type II diabetes mellitus

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ADP-ribosyltransferase 3	VGNC:10821	461241
Macaque	ADP-ribosyltransferase 3		100424030
Mouse	ADP-ribosyltransferase 3	MGI:1202729	109979
Rat	ADP-ribosyltransferase 3	RGD:628833	305235
Dog	ADP-ribosyltransferase 3	VGNC:38148	478434

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ADP-ribosyltransferase 3
Macaque	ADP-ribosyltransferase 3
Mouse	ADP-ribosyltransferase 3
Rat	ADP-ribosyltransferase 3
Dog	ADP-ribosyltransferase 3

Publication Statistics

PubMed Score 35.38

PubMed score by year

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PubTator Score 51.85

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (7)

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10

0 of 0

PMID	Year	Title