You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ART3
Ecto-ADP-ribosyltransferase 3

Protein Summary
Description
This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341029
  • ENSP00000343843
  • ENSG00000156219
  • ENST00000349321
  • ENSP00000304313
  • ENST00000355810
  • ENSP00000348064

Symbol
  • TMART
  • ARTC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
gene perturbation
0.8
disease perturbation
0.62
co-expressed gene
0.57
disease
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.38   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.38   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.996256748
p_ni:  0.003743209
p_wrong:  4.3e-8
Score:  0.245
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.984380962
p_ni:  0.015619035
p_wrong:  3e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
ITGA8
Tbio
Novelty:  0.0220023
p_int:  0.950744602
p_ni:  0.042805207
p_wrong:  0.006450191
Data Source:  BioPlex
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.914626837
p_ni:  0.085373163
Score:  0.191
Data Source:  BioPlex,STRINGDB
NAGLU
Tbio
Family:  Enzyme
Novelty:  0.01033079
p_int:  0.827343871
p_ni:  0.172656129
Score:  0.177
Data Source:  BioPlex,STRINGDB
POGLUT1
Tbio
Family:  Enzyme
Novelty:  0.03821516
p_int:  0.821146282
p_ni:  0.178853695
p_wrong:  2.3e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
HSPA12A
Tbio
Novelty:  0.11999085
p_int:  0.808699894
p_ni:  0.191300105
Score:  0.22
Data Source:  BioPlex,STRINGDB
PAM
Tchem
Family:  Enzyme
Novelty:  0.00378397
p_int:  0.759011932
p_ni:  0.240988048
p_wrong:  2e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
ART4
Tbio
Family:  Enzyme
Novelty:  0.15332159
Score:  0.93
Data Source:  STRINGDB
CD109
Tbio
Novelty:  0.01280272
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
2
2
0
1.7
91.4
body mass index
3
2
4
64.8
fetal genotype effect measurement
1
1
1
61.4
protein measurement
1
1
1
61.4
monokine induced by gamma interferon measurement
1
2
2
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
0
1.7
91.4
body mass index
4
64.8
fetal genotype effect measurement
1
61.4
protein measurement
1
61.4
monokine induced by gamma interferon measurement
2
57.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP-ribosyltransferase 3
VGNC:10821
461241
Macaque
ADP-ribosyltransferase 3
100424030
Mouse
MGI:1202729
109979
Rat
RGD:628833
305235
Dog
ADP-ribosyltransferase 3
VGNC:38148
478434
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP-ribosyltransferase 3
Macaque
ADP-ribosyltransferase 3
Mouse
Rat
Dog
ADP-ribosyltransferase 3
Publication Statistics
PubMed Score 35.38
PubMed score by year
PubTator Score 51.85
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title