Tbio ART3 Ecto-ADP-ribosyltransferase 3

Protein Summary

Description

This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q13508
• Q53XW3
• Q6FHT7
• Q8WVJ7
• Q93069
• Q96HL1

Gene Name

• ART3

Ensembl ID

• ENST00000341029
• ENSP00000343843
• ENSG00000156219
• ENST00000349321
• ENSP00000304313
• ENST00000355810
• ENSP00000348064

Symbol

• TMART
• ARTC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
gene perturbation	0.8
disease perturbation	0.62
co-expressed gene	0.57
disease	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.33   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 356   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.33   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0