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Tchem
TRPC3
Short transient receptor potential channel 3

Protein Summary
Description
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264811
  • ENSP00000264811
  • ENSG00000138741
  • ENST00000379645
  • ENSP00000368966

Symbol
  • TRP3
  • TRP3
  • SCA41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
hub protein
0.82
metabolite
0.82
biological process
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 386.85   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 386.85   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
norgestimate
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
56.9
mean reticulocyte volume
1
1
1
56.8
mean platelet volume
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
56.9
mean reticulocyte volume
1
56.8
mean platelet volume
1
2.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 3
VGNC:7428
471294
Macaque
transient receptor potential cation channel subfamily C member 3
707586
Mouse
MGI:109526
22065
Rat
RGD:61973
60395
Dog
transient receptor potential cation channel subfamily C member 3
VGNC:47867
483844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 3
Macaque
transient receptor potential cation channel subfamily C member 3
Mouse
Rat
Dog
transient receptor potential cation channel subfamily C member 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13507-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (275)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Effects of PIP2 hydrolysis
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
G alpha (q) signalling events
Protein-Protein Interactions (99)
1 – 10 of 99
TRPC7
Tchem
Family: IC
Novelty: 0.0033307
p_int: 0.999957691
p_wrong: 0.000042309
Score: 0.93
Data Source: BioPlex,STRINGDB
SEC24B
Tbio
Novelty: 0.01031644
p_int: 0.985334924
p_ni: 0.014665076
Data Source: BioPlex
SELENOO
Tdark
Novelty: 0.02959704
p_int: 0.945241063
p_ni: 0.05296821
p_wrong: 0.001790726
Data Source: BioPlex
SEC24A
Tbio
Novelty: 0.07724534
p_int: 0.93393751
p_ni: 0.06606249
Data Source: BioPlex
USP33
Tbio
Family: Enzyme
Novelty: 0.04411285
p_int: 0.922942459
p_ni: 0.077044193
p_wrong: 0.000013348
Data Source: BioPlex
RNF181
Tbio
Family: Enzyme
Novelty: 0.27482636
p_int: 0.908715654
p_ni: 0.089286319
p_wrong: 0.001998027
Data Source: BioPlex
PDLIM7
Tbio
Novelty: 0.00544518
p_int: 0.860434452
p_ni: 0.139563222
p_wrong: 0.000002326
Data Source: BioPlex
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.96
Data Source: STRINGDB
TRPC1
Tbio
Family: IC
Novelty: 0.00233677
Score: 0.947
Data Source: Reactome,STRINGDB
TRPC4
Tchem
Family: IC
Novelty: 0.00339889
Score: 0.942
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  386.85

PubMed score by year
PubTator Score  229.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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