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Tbio
MED21
Mediator of RNA polymerase II transcription subunit 21

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282892
  • ENSP00000282892
  • ENSG00000152944

Symbol
  • SRB7
  • SURB7
  • SRB7
  • SURB7
  • hSrb7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
protein complex
0.72
transcription factor binding site profile
0.65
cellular component
0.63
hub protein
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (198)
MED7
Tbio
Family:  Enzyme
Novelty:  0.04773947
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCNC
Tbio
Novelty:  0.00585842
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  1
Score:  0.988
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  1
Score:  0.987
Data Source:  BioPlex,STRINGDB
MED26
Tbio
Family:  Enzyme
Novelty:  0.05663538
p_int:  0.999999984
p_ni:  1.5e-8
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
MED27
Tbio
Family:  Enzyme
Novelty:  0.02511389
p_int:  0.999999979
p_ni:  2e-8
p_wrong:  1e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
MED30
Tbio
Family:  Enzyme
Novelty:  0.08618054
p_int:  0.999999969
p_ni:  3e-8
Score:  0.986
Data Source:  BioPlex,STRINGDB
MED9
Tbio
Family:  Enzyme
Novelty:  0.19660296
p_int:  0.999999958
p_ni:  4.1e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
MED13
Tbio
Family:  Enzyme
Novelty:  0.02090708
p_int:  0.999999953
p_ni:  4.7e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
1
1
62.1
self reported educational attainment
1
1
1
57.8
basophil count
2
1
2
52
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
62.1
self reported educational attainment
1
57.8
basophil count
2
52
1
49.5
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 21
VGNC:5469
465356
Macaque
mediator complex subunit 21
710699
Mouse
MGI:1347064
108098
Rat
RGD:1309836
312849
Dog
mediator complex subunit 21
477664
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 21
Macaque
mediator complex subunit 21
Mouse
Rat
Dog
mediator complex subunit 21
Publication Statistics
PubMed Score 14.97
PubMed score by year
PubTator Score 6.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title