Tbio MED21 Mediator of RNA polymerase II transcription subunit 21

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q13503
• B2R4I3
• Q6IB05
• Q92811

Gene Name

• MED21

Ensembl ID

• ENST00000282892
• ENSP00000282892
• ENSG00000152944

Symbol

• SRB7
• SURB7
• SRB7
• SURB7
• hSrb7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
protein complex	0.72
transcription factor binding site profile	0.65
cellular component	0.63
hub protein	0.63

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mediator Of Rna Polymerase Ii Transcription Subunit 21

DTO Classes

Protein / Transcription Factor / Mediator Of Rna Polymerase Ii Transcription Subunit 21

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.68   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.68   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0