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Tbio
SQSTM1
Sequestosome-1

Protein Summary
Description
Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune respons ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360718
  • ENSP00000353944
  • ENSG00000161011
  • ENST00000389805
  • ENSP00000374455

Symbol
  • ORCA
  • OSIL
  • p60
  • p62
  • A170
  • DMRV
  • OSIL
  • PDB3
  • ZIP3
  • p62B
  • NADGP
  • FTDALS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
biological process
0.96
drug perturbation
0.96
transcription factor perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1093.21   (req: < 5)
Gene RIFs: 324   (req: <= 3)
Antibodies: 1081   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1093.21   (req: >= 5)
Gene RIFs: 324   (req: > 3)
Antibodies: 1081   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
71.3
monocyte percentage of leukocytes
1
1
1
50.6
lymphocyte count
1
1
1
43.5
neutrophil percentage of leukocytes
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
71.3
monocyte percentage of leukocytes
1
50.6
lymphocyte count
1
43.5
neutrophil percentage of leukocytes
1
9.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sequestosome 1
VGNC:4180
462333
Macaque
sequestosome 1
705481
Mouse
MGI:107931
18412
Rat
RGD:69287
113894
Dog
sequestosome 1
VGNC:46787
481459
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sequestosome 1
Macaque
sequestosome 1
Mouse
Rat
Dog
sequestosome 1
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13501-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (122)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Cellular responses to external stimuli
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Autophagy
Cell death signalling via NRAGE, NRIF and NADE
Cellular responses to external stimuli
Cytokine Signaling in Immune system
Death Receptor Signalling
Gene Ontology Terms (64)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (336)
1 – 10 of 336
RETN
Tbio
Novelty: 0.00062517
p_int: 0.997093079
p_ni: 0.002906921
Score: 0.187
Data Source: BioPlex,STRINGDB
EDDM3B
Tdark
Novelty: 0.12874735
p_int: 0.98461159
p_ni: 0.01538841
Data Source: BioPlex
KERA
Tbio
Novelty: 0.00789599
p_int: 0.979900907
p_ni: 0.020099093
Score: 0.202
Data Source: BioPlex,STRINGDB
PRKCZ
Tchem
Family: Kinase
Novelty: 0.00201366
p_int: 0.971148548
p_ni: 0.028851452
Score: 0.955
Data Source: BioPlex,STRINGDB
INSL5
Tbio
Novelty: 0.04351334
p_int: 0.971088926
p_ni: 0.028911074
Data Source: BioPlex
TMX1
Tbio
Novelty: 0.03444237
p_int: 0.96615906
p_ni: 0.03384094
Data Source: BioPlex
VWCE
Tbio
Novelty: 0.09328341
p_int: 0.963341853
p_ni: 0.036658147
Score: 0.243
Data Source: BioPlex,STRINGDB
CD96
Tbio
Novelty: 0.02087722
p_int: 0.952239612
p_ni: 0.047760388
Score: 0.187
Data Source: BioPlex,STRINGDB
IL17F
Tbio
Novelty: 0.00223549
p_int: 0.94672289
p_ni: 0.05327711
Data Source: BioPlex
IL7R
Tbio
Novelty: 0.00107223
p_int: 0.929257106
p_ni: 0.070742894
Data Source: BioPlex
Publication Statistics
PubMed Score  1093.21

PubMed score by year
PubTator Score  598.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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