Protein Summary
Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune respons ...more
- ENST00000360718
- ENSP00000353944
- ENSG00000161011
- ENST00000389805
- ENSP00000374455
- ORCA
- OSIL
- p60
- p62
- A170
- DMRV
- OSIL
- PDB3
- ZIP3
- p62B
- NADGP
- FTDALS3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
biological process | 0.96 | ||
drug perturbation | 0.96 | ||
transcription factor perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1156.84 (req: < 5)
Gene RIFs: 324 (req: <= 3)
Antibodies: 1081 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1156.84 (req: >= 5)
Gene RIFs: 324 (req: > 3)
Antibodies: 1081 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 45
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (336)
RETN
Novelty: 0.00062517
p_int: 0.997093079
p_ni: 0.002906921
Score: 0.187
Data Source: BioPlex,STRINGDB
KERA
Novelty: 0.00789599
p_int: 0.979900907
p_ni: 0.020099093
Score: 0.202
Data Source: BioPlex,STRINGDB
PRKCZ
Family: Kinase
Novelty: 0.00201366
p_int: 0.971148548
p_ni: 0.028851452
Score: 0.955
Data Source: BioPlex,STRINGDB
VWCE
Novelty: 0.09328341
p_int: 0.963341853
p_ni: 0.036658147
Score: 0.243
Data Source: BioPlex,STRINGDB
CD96
Novelty: 0.02087722
p_int: 0.952239612
p_ni: 0.047760388
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (122)
Reactome (18)
KEGG (6)
PathwayCommons (6)
WikiPathways (92)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Death Receptor Signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Autophagy | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Cellular responses to external stimuli | ||||
Cytokine Signaling in Immune system | ||||
Death Receptor Signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (64)
Functions (13)
Components (19)
Processes (32)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 3 | 3 | 85.6 | |||||
monocyte percentage of leukocytes | 2 | 2 | 2 | 82.3 | |||||
granulocyte percentage of myeloid white cells | 1 | 1 | 1 | 76.6 | |||||
monocyte count | 1 | 1 | 1 | 73.2 | |||||
lymphocyte count | 2 | 2 | 2 | 57.6 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil count | 3 | 85.6 | |||||
monocyte percentage of leukocytes | 2 | 82.3 | |||||
granulocyte percentage of myeloid white cells | 1 | 76.6 | |||||
monocyte count | 1 | 73.2 | |||||
lymphocyte count | 2 | 57.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | sequestosome 1 | VGNC:4180 | 462333 | |||||
Macaque | sequestosome 1 | 705481 | ||||||
Mouse | MGI:107931 | 18412 | ||||||
Rat | RGD:69287 | 113894 | ||||||
Dog | sequestosome 1 | VGNC:46787 | 481459 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | sequestosome 1 | |||||
Macaque | sequestosome 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sequestosome 1 | |||||
Publication Statistics
PubMed Score 1156.84
PubMed score by year
PubTator Score 598.55
PubTator score by year
Related Publications
Text Mined References (421)
GeneRif Annotations (324)
Items per page:
0 of 0
PMID | Year | Title |
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