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Tbio
MTM1
Myotubularin

Protein Summary
Description
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370396
  • ENSP00000359423
  • ENSG00000171100

Symbol
  • CG2
  • CNM
  • MTMX
  • XLMTM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
kinase perturbation
0.81
disease perturbation
0.79
molecular function
0.79
cellular component
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.33   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.33   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
TRIML2
Tdark
Family:  Enzyme
Novelty:  0.38455379
p_int:  1
Score:  0.227
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.985932427
p_ni:  0.014067573
Score:  0.159
Data Source:  BioPlex,STRINGDB
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.977387115
p_ni:  0.022612885
Score:  0.234
Data Source:  BioPlex,STRINGDB
PIKFYVE
Tchem
Family:  Kinase
Novelty:  0.00441336
Score:  0.963
Data Source:  STRINGDB
MTMR12
Tbio
Novelty:  0.11861954
Score:  0.95
Data Source:  Reactome,STRINGDB
KMT2A
Tchem
Family:  Epigenetic
Novelty:  0.00192554
Score:  0.926
Data Source:  STRINGDB
INPP4A
Tbio
Family:  Enzyme
Novelty:  0.03714963
Score:  0.919
Data Source:  STRINGDB
INPP4B
Tbio
Family:  Enzyme
Novelty:  0.02053228
Score:  0.912
Data Source:  STRINGDB
IMPA1
Tclin
Family:  Enzyme
Novelty:  0.00766053
Score:  0.909
Data Source:  STRINGDB
CDIPT
Tbio
Family:  Enzyme
Novelty:  0.00560887
Score:  0.903
Data Source:  STRINGDB
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the early endosome membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the early endosome membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
56.6
hematocrit
1
1
1
54.4
hemoglobin measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
56.6
hematocrit
1
54.4
hemoglobin measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
myotubularin 1
703131
Mouse
MGI:1099452
17772
Rat
RGD:1304582
288762
Dog
myotubularin 1
VGNC:43477
612385
Horse
myotubularin 1
VGNC:20419
100069680
Species
Name
OMA
EggNOG
Inparanoid
Macaque
myotubularin 1
Mouse
Rat
Dog
myotubularin 1
Horse
myotubularin 1
Publication Statistics
PubMed Score 271.33
PubMed score by year
PubTator Score 178.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title