Protein Summary
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene h ...more
- ENST00000370396
- ENSP00000359423
- ENSG00000171100
- CG2
- CNM
- MTMX
- XLMTM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
kinase perturbation | 0.81 | ||
disease perturbation | 0.79 | ||
molecular function | 0.79 | ||
cellular component | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 271.33 (req: < 5)
Gene RIFs: 48 (req: <= 3)
Antibodies: 288 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 271.33 (req: >= 5)
Gene RIFs: 48 (req: > 3)
Antibodies: 288 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (96)
TUBA3C
Novelty: 0.0187396
p_int: 0.985932427
p_ni: 0.014067573
Score: 0.159
Data Source: BioPlex,STRINGDB
SNX17
Novelty: 0.03960737
p_int: 0.977387115
p_ni: 0.022612885
Score: 0.234
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (10)
Reactome (7)
KEGG (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PI Metabolism | ||||
Reactome | Phospholipid metabolism | ||||
Reactome | Synthesis of PIPs at the early endosome membrane | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of lipids | ||||
PI Metabolism | ||||
Phospholipid metabolism | ||||
Synthesis of PIPs at the early endosome membrane | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (6)
Components (7)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 1 | 1 | 56.6 | |||||
hematocrit | 1 | 1 | 1 | 54.4 | |||||
hemoglobin measurement | 1 | 1 | 1 | 38.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 56.6 | |||||
hematocrit | 1 | 54.4 | |||||
hemoglobin measurement | 1 | 38.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | myotubularin 1 | 703131 | ||||||
Mouse | MGI:1099452 | 17772 | ||||||
Rat | RGD:1304582 | 288762 | ||||||
Dog | myotubularin 1 | VGNC:43477 | 612385 | |||||
Horse | myotubularin 1 | VGNC:20419 | 100069680 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | myotubularin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | myotubularin 1 | |||||
Horse | myotubularin 1 | |||||
Publication Statistics
PubMed Score 271.33
PubMed score by year
PubTator Score 178.71
PubTator score by year
Related Publications
Text Mined References (71)
GeneRif Annotations (48)
Items per page:
0 of 0
PMID | Year | Title |
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