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Tbio
PICALM
Phosphatidylinositol-binding clathrin assembly protein

Protein Summary
Description
Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356360
  • ENSP00000348718
  • ENSG00000073921
  • ENST00000393346
  • ENSP00000377015
  • ENST00000526033
  • ENSP00000433846
  • ENST00000528398
  • ENSP00000434884
  • ENST00000532317
  • ENSP00000436958

Symbol
  • CALM
  • LAP
  • CALM
  • CLTH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.97
virus perturbation
0.97
biological process
0.95
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.18   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.18   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (262)
1 – 10 of 262
CLTCL1
Tbio
Novelty:  0.05667807
p_int:  0.999982724
p_ni:  0.000017276
Score:  0.983
Data Source:  BioPlex,STRINGDB
BMP2K
Tchem
Family:  Kinase
Novelty:  0.10145601
p_int:  0.999954359
p_ni:  0.000045641
Score:  0.876
Data Source:  BioPlex,STRINGDB
PIK3C2A
Tchem
Family:  Kinase
Novelty:  0.0002219
p_int:  0.99986396
p_ni:  0.000136033
p_wrong:  6e-9
Score:  0.971
Data Source:  BioPlex,STRINGDB
STAMBPL1
Tbio
Family:  Enzyme
Novelty:  0.08532786
p_int:  0.999529058
p_ni:  0.000470942
Score:  0.826
Data Source:  BioPlex,STRINGDB
GTSE1
Tbio
Family:  Enzyme
Novelty:  0.0460569
p_int:  0.995942244
p_ni:  0.004057755
Score:  0.604
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.972074487
p_ni:  0.027925513
Score:  0.984
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.969693083
p_ni:  0.030306916
Score:  0.524
Data Source:  BioPlex,STRINGDB
CLINT1
Tbio
Novelty:  0.00945381
p_int:  0.943880344
p_ni:  0.056119656
Score:  0.995
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
p_int:  0.848059761
p_ni:  0.151940239
Score:  0.989
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.76823135
p_ni:  0.231758885
p_wrong:  0.000009765
Data Source:  BioPlex
Pathways (6)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (63)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
Alzheimers_University_of_Toronto
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
12
7
0
1.2
95.9
family history of Alzheimer’s disease
3
3
0
1.1
91.3
platelet count
2
2
2
79.8
mean platelet volume
2
2
2
55.2
serum albumin measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
95.9
family history of Alzheimer’s disease
0
1.1
91.3
platelet count
2
79.8
mean platelet volume
2
55.2
serum albumin measurement
1
30.2
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol binding clathrin assembly protein
VGNC:3070
451725
Macaque
phosphatidylinositol binding clathrin assembly protein
706003
Mouse
MGI:2385902
233489
Rat
RGD:621054
89816
Dog
phosphatidylinositol binding clathrin assembly protein
VGNC:44524
476780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol binding clathrin assembly protein
Macaque
phosphatidylinositol binding clathrin assembly protein
Mouse
Rat
Dog
phosphatidylinositol binding clathrin assembly protein
Publication Statistics
PubMed Score 122.18
PubMed score by year
PubTator Score 97.91
PubTator score by year