Tbio PICALM Phosphatidylinositol-binding clathrin assembly protein

Protein Summary

Description

Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q13492
• B4DTM3
• E9PN05
• F8VPG7
• O60700
• Q4LE54
• Q6GMQ6
• Q86XZ9

Gene Name

• PICALM

Ensembl ID

• ENST00000356360
• ENSP00000348718
• ENSG00000073921
• ENST00000393346
• ENSP00000377015
• ENST00000526033
• ENSP00000433846
• ENST00000528398
• ENSP00000434884
• ENST00000532317
• ENSP00000436958

Symbol

• CALM
• LAP
• CALM
• CLTH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
transcription factor perturbation	0.97
virus perturbation	0.97
biological process	0.95
disease perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Phosphatidylinositol-binding Clathrin Assembly Protein

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Phosphatidylinositol-binding Clathrin Assembly Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.55   (req: < 5)

Gene RIFs: 104   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.55   (req: >= 5)

Gene RIFs: 104   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0