PICALM
Phosphatidylinositol-binding clathrin assembly protein
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.99 | ||
transcription factor perturbation | 0.97 | ||
virus perturbation | 0.97 | ||
biological process | 0.95 | ||
disease perturbation | 0.93 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Golgi Associated Vesicle Biogenesis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Golgi Associated Vesicle Biogenesis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | Alzheimers_University_of_Toronto | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
12 | 7 | 0 | 1.2 | 95.9 | |||||
family history of Alzheimer’s disease | 3 | 3 | 0 | 1.1 | 91.3 | ||||
platelet count | 2 | 2 | 2 | 79.8 | |||||
mean platelet volume | 2 | 2 | 2 | 55.2 | |||||
serum albumin measurement | 1 | 1 | 1 | 30.2 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 95.9 | |||||
family history of Alzheimer’s disease | 0 | 1.1 | 91.3 | ||||
platelet count | 2 | 79.8 | |||||
mean platelet volume | 2 | 55.2 | |||||
serum albumin measurement | 1 | 30.2 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | phosphatidylinositol binding clathrin assembly protein | VGNC:3070 | 451725 | |||||
Macaque | phosphatidylinositol binding clathrin assembly protein | 706003 | ||||||
Mouse | MGI:2385902 | 233489 | ||||||
Rat | RGD:621054 | 89816 | ||||||
Dog | phosphatidylinositol binding clathrin assembly protein | VGNC:44524 | 476780 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | phosphatidylinositol binding clathrin assembly protein | |||||
Macaque | phosphatidylinositol binding clathrin assembly protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphatidylinositol binding clathrin assembly protein | |||||
PMID | Year | Title |
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