You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
BIRC2
Baculoviral IAP repeat-containing protein 2

Protein Summary
Description
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227758
  • ENSP00000227758
  • ENSG00000110330
  • ENST00000530675
  • ENSP00000431723
  • ENST00000613397
  • ENSP00000477613

Symbol
  • API1
  • MIHB
  • RNF48
  • API1
  • MIHB
  • HIAP2
  • RNF48
  • cIAP1
  • Hiap-2
  • c-IAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.99
chemical
0.95
virus perturbation
0.94
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 456.36   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 447   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 456.36   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 447   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 444
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (60)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Cytokine Signaling in Immune system
Death Receptor Signalling
Gene Ontology Terms (53)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (290)
1 – 10 of 290
TRAF2
Tbio
Novelty: 0.00983658
p_int: 1
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
DIABLO
Tbio
Novelty: 0.0007851
p_int: 0.99999986
p_ni: 1.4e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
p_int: 0.99999919
p_ni: 8.1e-7
Score: 0.989
Data Source: BioPlex,STRINGDB
PDIA5
Tbio
Family: Enzyme
Novelty: 0.06234465
p_int: 0.999996205
p_ni: 0.000003795
Data Source: BioPlex
CXCL1
Tbio
Novelty: 0.00059123
p_int: 0.999995556
p_ni: 0.000004444
Score: 0.214
Data Source: BioPlex,STRINGDB
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.999992331
p_ni: 0.000007668
p_wrong: 1e-9
Data Source: BioPlex
CXCL3
Tbio
Novelty: 0.01001656
p_int: 0.999967534
p_ni: 0.000032466
Data Source: BioPlex
LRRN2
Tdark
Novelty: 0.22583761
p_int: 0.999963181
p_ni: 0.000036818
p_wrong: 1e-9
Score: 0.341
Data Source: BioPlex,STRINGDB
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999936348
p_ni: 0.000063651
p_wrong: 2e-9
Score: 0.959
Data Source: BioPlex,Reactome,STRINGDB
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.999928866
p_ni: 0.000071134
Data Source: BioPlex
Publication Statistics
PubMed Score  456.36

PubMed score by year
PubTator Score  319.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer