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Tchem
BIRC2
Baculoviral IAP repeat-containing protein 2

Protein Summary
Description
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227758
  • ENSP00000227758
  • ENSG00000110330
  • ENST00000530675
  • ENSP00000431723
  • ENST00000613397
  • ENSP00000477613

Symbol
  • API1
  • MIHB
  • RNF48
  • API1
  • MIHB
  • HIAP2
  • RNF48
  • cIAP1
  • Hiap-2
  • c-IAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.99
chemical
0.95
virus perturbation
0.94
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.53   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 447   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.53   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 447   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 525
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0