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Tchem
BIRC3
Baculoviral IAP repeat-containing protein 3

Protein Summary
Description
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263464
  • ENSP00000263464
  • ENSG00000023445
  • ENST00000532808
  • ENSP00000432907
  • ENST00000615299
  • ENSP00000481903

Symbol
  • API2
  • MIHC
  • RNF49
  • AIP1
  • API2
  • MIHC
  • CIAP2
  • HAIP1
  • HIAP1
  • IAP-1
  • MALT2
  • RNF49
  • c-IAP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological process
0.96
gene perturbation
0.95
chemical
0.93
biological term
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 485.09   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 635   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 485.09   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 635   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 1 measurement
1
1
1
60.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 1 measurement
1
60.7
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (151)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Reactome
Deubiquitination
Reactome
IKK complex recruitment mediated by RIP1
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Death Receptor Signalling
Deubiquitination
IKK complex recruitment mediated by RIP1
Immune System
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (253)
1 – 10 of 253
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.999
Data Source: Reactome,STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
Score: 0.997
Data Source: Reactome,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
Score: 0.995
Data Source: STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.995
Data Source: Reactome,STRINGDB
RIPK2
Tchem
Family: Kinase
Novelty: 0.00574043
Score: 0.993
Data Source: STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.993
Data Source: STRINGDB
DIABLO
Tbio
Novelty: 0.0007851
Score: 0.991
Data Source: STRINGDB
CD40
Tchem
Novelty: 0.0002836
Score: 0.991
Data Source: Reactome,STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.988
Data Source: STRINGDB
UBE2D3
Tbio
Novelty: 0.01908446
Score: 0.988
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  485.09

PubMed score by year
PubTator Score  415.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer