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Tbio
SMAD4
Mothers against decapentaplegic homolog 4

Protein Summary
Description
In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the mul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342988
  • ENSP00000341551
  • ENSG00000141646
  • ENST00000398417
  • ENSP00000381452

Symbol
  • DPC4
  • MADH4
  • JIP
  • DPC4
  • MADH4
  • MYHRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
interacting protein
0.96
kinase perturbation
0.95


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2109.65   (req: < 5)
Gene RIFs: 424   (req: <= 3)
Antibodies: 815   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2109.65   (req: >= 5)
Gene RIFs: 424   (req: > 3)
Antibodies: 815   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 88
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (490)
SKIL
Tbio
Novelty:  0.00788464
p_int:  0.999999999
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SKI
Tbio
Novelty:  0.02109924
p_int:  0.999999955
p_ni:  2.7e-8
p_wrong:  1.8e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
p_int:  0.999999798
p_wrong:  2.02e-7
Score:  0.344
Data Source:  BioPlex,STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
p_int:  0.999703251
p_ni:  0.00005911
p_wrong:  0.00023764
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.997910054
p_ni:  0.001522325
p_wrong:  0.000567621
Data Source:  BioPlex
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.997
Data Source:  Reactome,STRINGDB
THOC5
Tbio
Novelty:  0.04618391
Score:  0.993
Data Source:  STRINGDB
TGFBR1
Tchem
Family:  Kinase
Novelty:  0.00081645
Score:  0.991
Data Source:  STRINGDB
TGFBRAP1
Tbio
Novelty:  0.05996919
Score:  0.99
Data Source:  STRINGDB
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
Score:  0.99
Data Source:  STRINGDB
Pathways (109)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Name
Explore in Pharos
Explore in Source
Deubiquitination
Developmental Biology
Disease
Diseases of signal transduction
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (97)
Find Similar Targets
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
CAFA
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
27.3
Eczema
1
1
0
1
27.3
1
2
0
1.1
27.2
childhood onset asthma
1
1
0
1.1
11.4
eosinophil count
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
27.3
Eczema
0
1
27.3
0
1.1
27.2
childhood onset asthma
0
1.1
11.4
eosinophil count
1
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMAD family member 4
VGNC:13288
468537
Macaque
SMAD family member 4
701803
Mouse
MGI:894293
17128
Rat
RGD:3033
50554
Dog
SMAD family member 4
VGNC:46521
476196
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMAD family member 4
Macaque
SMAD family member 4
Mouse
Rat
Dog
SMAD family member 4
Publication Statistics
PubMed Score 2109.65
PubMed score by year
PubTator Score 1173.72
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title