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Tchem
GAB1
GRB2-associated-binding protein 1

Protein Summary
Description
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262994
  • ENSP00000262994
  • ENSG00000109458
  • ENST00000262995
  • ENSP00000262995

Symbol
  • DFNB26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
hub protein
0.94
disease perturbation
0.93
kinase
0.88
transcription factor binding site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.28   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.28   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (176)
1 – 10 of 176
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999665
p_ni:  3.35e-7
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
GRAP2
Tbio
Novelty:  0.00503901
p_int:  0.999998408
p_ni:  0.000001588
p_wrong:  4e-9
Score:  0.722
Data Source:  BioPlex,STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
p_int:  0.999619037
p_ni:  0.000380036
p_wrong:  9.27e-7
Score:  0.534
Data Source:  BioPlex,STRINGDB
LGALS7
Tbio
Novelty:  0.00753996
p_int:  0.989097478
p_ni:  0.010902515
p_wrong:  8e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
TUFM
Tchem
Novelty:  0.03251632
p_int:  0.978812982
p_ni:  0.021187011
p_wrong:  7e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
ARL4C
Tbio
Family:  Enzyme
Novelty:  0.04764628
p_int:  0.899969012
p_ni:  0.055287419
p_wrong:  0.044743568
Score:  0.209
Data Source:  BioPlex,STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.999
Data Source:  Reactome,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.986
Data Source:  Reactome,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.981
Data Source:  STRINGDB
CRK
Tchem
Novelty:  0.00238512
Score:  0.981
Data Source:  Reactome,STRINGDB
Pathways (113)
Activated NTRK2 signals through PI3K (R-HSA-9028335)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 65
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through PI3K
Reactome
Axon guidance
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Constitutive Signaling by EGFRvIII
Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through PI3K
Axon guidance
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
67.7
urate measurement
1
1
1
11.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
9.2
Diuretic use measurement
1
1
1
7.8
body height
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
67.7
urate measurement
1
11.6
Agents acting on the renin-angiotensin system use measurement
1
9.2
Diuretic use measurement
1
7.8
body height
1
6
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRB2 associated binding protein 1
VGNC:2988
461516
Macaque
GRB2 associated binding protein 1
700367
Mouse
MGI:108088
14388
Rat
RGD:1311085
361388
Dog
GRB2 associated binding protein 1
VGNC:41045
483808
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRB2 associated binding protein 1
Macaque
GRB2 associated binding protein 1
Mouse
Rat
Dog
GRB2 associated binding protein 1
Publication Statistics
PubMed Score 59.28
PubMed score by year
PubTator Score 125.45
PubTator score by year