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Tbio
IL18R1
Interleukin-18 receptor 1

Protein Summary
Description
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233957
  • ENSP00000233957
  • ENSG00000115604
  • ENST00000409599
  • ENSP00000387211
  • ENST00000410040
  • ENSP00000386663

Symbol
  • IL1RRP
  • CD218a
  • IL18RA
  • IL1RRP
  • CDw218a
  • IL-1Rrp
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease
0.73
gene perturbation
0.72
biological process
0.71
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.82   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.82   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
16
9
1
1.2
99.8
4
3
0
1.2
99
Eczema
3
3
0
1.1
99
eosinophil count
6
8
7
6.4
98.9
serum ST2 measurement
1
5
5
97.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
99.8
0
1.2
99
Eczema
0
1.1
99
eosinophil count
7
6.4
98.9
serum ST2 measurement
5
97.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 18 receptor 1
VGNC:318
459463
Macaque
interleukin 18 receptor 1
100426588
Mouse
MGI:105383
16182
Rat
RGD:1308589
301365
Dog
interleukin 18 receptor 1
VGNC:41953
611438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 18 receptor 1
Macaque
interleukin 18 receptor 1
Mouse
Rat
Dog
interleukin 18 receptor 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13478-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-18 signaling
Reactome
Interleukin-37 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-18 signaling
Interleukin-37 signaling
Protein-Protein Interactions (72)
1 – 10 of 72
IL18
Tbio
Novelty: 0.00022844
Score: 0.995
Data Source: Reactome,STRINGDB
IL18RAP
Tbio
Novelty: 0.0141773
Score: 0.991
Data Source: Reactome,STRINGDB
IL37
Tbio
Novelty: 0.00499186
Score: 0.959
Data Source: Reactome,STRINGDB
IL18BP
Tbio
Novelty: 0.00838895
Score: 0.954
Data Source: STRINGDB
STAT4
Tbio
Family: TF
Novelty: 0.00251747
Score: 0.948
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.927
Data Source: STRINGDB
NFKB1
Tclin
Family: TF
Novelty: 0.00198195
Score: 0.921
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.92
Data Source: STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.918
Data Source: STRINGDB
SIGIRR
Tbio
Novelty: 0.01438984
Score: 0.917
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  53.82

PubMed score by year
PubTator Score  201.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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