Tbio IL18R1 Interleukin-18 receptor 1

Protein Summary

Description

Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q13478
• B2R9Y5
• Q52LC9
• IL-18R-1

Gene Name

• IL18R1

Ensembl ID

• ENST00000233957
• ENSP00000233957
• ENSG00000115604
• ENST00000409599
• ENSP00000387211
• ENST00000410040
• ENSP00000386663

Symbol

• IL1RRP
• CD218a
• IL18RA
• IL1RRP
• CDw218a
• IL-1Rrp

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
disease	0.73
gene perturbation	0.72
biological process	0.71
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-18 Receptor 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-18 Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.61   (req: < 5)

Gene RIFs: 59   (req: <= 3)

Antibodies: 720   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.61   (req: >= 5)

Gene RIFs: 59   (req: > 3)

Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0