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Tbio
MADCAM1
Mucosal addressin cell adhesion molecule 1

Protein Summary
Description
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215637
  • ENSP00000215637
  • ENSG00000099866
  • ENST00000346144
  • ENSP00000304247
  • ENST00000382683
  • ENSP00000372130

Symbol
  • MACAM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
cell line
0.58
protein domain
0.58
tissue
0.55
tissue sample
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.9   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 660   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.9   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 660   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mucosal vascular addressin cell adhesion molecule 1
VGNC:11178
104003219
Mouse
MGI:103579
17123
Rat
RGD:3029
54266
Dog
mucosal vascular addressin cell adhesion molecule 1
VGNC:42916
485103
Cow
mucosal vascular addressin cell adhesion molecule 1
VGNC:31133
527275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mucosal vascular addressin cell adhesion molecule 1
Mouse
Rat
Dog
mucosal vascular addressin cell adhesion molecule 1
Cow
mucosal vascular addressin cell adhesion molecule 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13477-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Extracellular matrix organization
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (68)
1 – 10 of 68
TCAF2
Tbio
Family: Enzyme
Novelty: 0.37070492
p_int: 0.999999341
p_ni: 6.59e-7
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
TMEM97
Tchem
Novelty: 0.00597439
p_int: 0.999980867
p_ni: 0.000019129
p_wrong: 5e-9
Score: 0.29
Data Source: BioPlex,STRINGDB
ARFGEF2
Tbio
Novelty: 0.05568966
p_int: 0.842975831
p_ni: 0.157024162
p_wrong: 7e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
ITGA4
Tclin
Novelty: 0.00197607
Score: 0.97
Data Source: Reactome,STRINGDB
ITGB7
Tclin
Novelty: 0.01290005
Score: 0.968
Data Source: Reactome,STRINGDB
SELL
Tchem
Novelty: 0.00030025
Score: 0.962
Data Source: Reactome,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.906
Data Source: STRINGDB
ACKR2
Tbio
Family: GPCR
Novelty: 0.00412934
Score: 0.826
Data Source: STRINGDB
CCR9
Tchem
Family: GPCR
Novelty: 0.00654663
Score: 0.823
Data Source: STRINGDB
NTAN1
Tbio
Family: Enzyme
Novelty: 0.01112132
Score: 0.794
Data Source: STRINGDB
Publication Statistics
PubMed Score  312.90

PubMed score by year
PubTator Score  133.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer