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Tbio
TOP3A
DNA topoisomerase 3-alpha

Protein Summary
Description
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321105
  • ENSP00000321636
  • ENSG00000177302
  • ENST00000542570
  • ENSP00000442336
  • ENST00000580095
  • ENSP00000462790
  • ENST00000638894
  • ENSP00000492229
  • ENSG00000284238
  • ENST00000639065
  • ENSP00000491260
  • ENST00000640743
  • ENSP00000491689

Symbol
  • TOP3
  • TOP3
  • PEOB5
  • ZGRF7
  • MGRISCE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.89
tissue
0.72
cellular component
0.7
histone modification site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.27   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.27   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
72.9
systolic blood pressure
1
1
1
72.9
BMI-adjusted waist-hip ratio
1
3
3
72.3
BMI-adjusted waist-hip ratio
1
3
3
72.3
waist-hip ratio
1
2
2
61.3
Items per page:
1 – 5 of 26
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
72.9
systolic blood pressure
1
72.9
BMI-adjusted waist-hip ratio
3
72.3
BMI-adjusted waist-hip ratio
3
72.3
waist-hip ratio
2
61.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA topoisomerase III alpha
VGNC:9733
454488
Macaque
DNA topoisomerase III alpha
700830
Mouse
MGI:1197527
21975
Rat
RGD:1309320
303194
Dog
DNA topoisomerase III alpha
VGNC:49633
489537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA topoisomerase III alpha
Macaque
DNA topoisomerase III alpha
Mouse
Rat
Dog
DNA topoisomerase III alpha
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13472-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (95)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
G2/M Checkpoints
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (241)
1 – 10 of 241
RMI2
Tbio
Novelty:  0.02516878
p_int:  0.999999737
p_ni:  2.61e-7
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
CCDC69
Tdark
Novelty:  0.37983713
p_int:  0.999997063
p_ni:  0.000002935
p_wrong:  1e-9
Score:  0.547
Data Source:  BioPlex,STRINGDB
RMI1
Tbio
Novelty:  0.01222442
p_int:  0.999719712
p_ni:  0.000280286
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
p_int:  0.998848411
p_ni:  0.001151562
p_wrong:  2.7e-8
Score:  0.245
Data Source:  BioPlex,STRINGDB
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.997061554
p_ni:  0.00293844
p_wrong:  6e-9
Data Source:  BioPlex
MARCKSL1
Tbio
Novelty:  0.01290798
p_int:  0.995861671
p_ni:  0.004137754
p_wrong:  5.74e-7
Score:  0.213
Data Source:  BioPlex,STRINGDB
LIG3
Tbio
Family:  Enzyme
Novelty:  0.00809038
p_int:  0.994951402
p_ni:  0.005048561
p_wrong:  3.7e-8
Score:  0.261
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.994627767
p_ni:  0.005372212
p_wrong:  2.1e-8
Data Source:  BioPlex
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.994507625
p_ni:  0.005492375
Data Source:  BioPlex
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.993002399
p_ni:  0.006997558
p_wrong:  4.3e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  164.27

PubMed score by year
PubTator Score  30.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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