Tchem TNK1 Non-receptor tyrosine-protein kinase TNK1

Protein Summary

Description

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q13470
• O95364
• Q8IYI4

Gene Name

• TNK1

Ensembl ID

• ENST00000570896
• ENSP00000458834
• ENSG00000174292
• ENST00000576812
• ENSP00000459799
• ENST00000639010
• ENSP00000491712
• ENSG00000283781
• ENST00000639430
• ENSP00000491136

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
molecular function	0.96
protein domain	0.92
small molecule	0.89
co-expressed gene	0.87

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Ack Family / Non-receptor Tyrosine-protein Kinase Tnk1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.98   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 334   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.98   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2