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Tchem
TNK1
Non-receptor tyrosine-protein kinase TNK1

Protein Summary
Description
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000570896
  • ENSP00000458834
  • ENSG00000174292
  • ENST00000576812
  • ENSP00000459799
  • ENST00000639010
  • ENSP00000491712
  • ENSG00000283781
  • ENST00000639430
  • ENSP00000491136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
molecular function
0.96
protein domain
0.92
small molecule
0.89
co-expressed gene
0.87


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.95   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.95   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tyrosine kinase non receptor 1
715180
Rat
RGD:1310113
303247
Dog
tyrosine kinase non receptor 1
VGNC:47679
489470
Horse
tyrosine kinase non receptor 1
VGNC:24384
100061776
Cow
tyrosine kinase non receptor 1
VGNC:36182
510356
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tyrosine kinase non receptor 1
Rat
Dog
tyrosine kinase non receptor 1
Horse
tyrosine kinase non receptor 1
Cow
tyrosine kinase non receptor 1
Pathways (106)
Items per page:
1 – 5 of 106
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Focal Adhesion
WikiPathways
Focal Adhesion
WikiPathways
Focal Adhesion
WikiPathways
Focal Adhesion
WikiPathways
RalA downstream regulated genes
Name
Explore in Pharos
Explore in Source
Focal Adhesion
Focal Adhesion
Focal Adhesion
Focal Adhesion
RalA downstream regulated genes
Protein-Protein Interactions (18)
1 – 10 of 18
CD38
Tclin
Family: Enzyme
Novelty: 0.00034991
Score: 0.646
Data Source: STRINGDB
PGBD1
Tbio
Novelty: 0.10454627
Score: 0.64
Data Source: STRINGDB
EXOC3L2
Tbio
Novelty: 0.16366061
Score: 0.63
Data Source: STRINGDB
PICALM
Tbio
Novelty: 0.00800832
Score: 0.513
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.513
Data Source: STRINGDB
GALP
Tbio
Novelty: 0.00153472
Score: 0.51
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.469
Data Source: STRINGDB
RND2
Tbio
Family: Enzyme
Novelty: 0.01278315
Score: 0.457
Data Source: STRINGDB
GAK
Tchem
Family: Kinase
Novelty: 0.00731928
Score: 0.448
Data Source: STRINGDB
PDZD4
Tbio
Novelty: 0.00603543
Score: 0.443
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.95

PubMed score by year
PubTator Score  9.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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