Tbio NFATC2 Nuclear factor of activated T-cells, cytoplasmic 2

Protein Summary

Description

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q13469
• B5B2N8
• B5B2N9
• B5B2P0
• B5B2P2
• B5B2P3
• Q13468
• Q5TFW7
• Q5TFW8
• Q9NPX6
• Q9NQH3
• Q9UJR2
• NF-ATc2

Gene Name

• NFATC2

Ensembl ID

• ENST00000371564
• ENSP00000360619
• ENSG00000101096
• ENST00000396009
• ENSP00000379330
• ENST00000414705
• ENSP00000396471
• ENST00000609507
• ENSP00000477342
• ENST00000609943
• ENSP00000477370
• ENST00000610033
• ENSP00000477142

Symbol

• NFAT1
• NFATP
• NFAT1
• NFATP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.94
biological process	0.87
protein domain	0.85
molecular function	0.84
transcription factor binding site profile	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 2

Protein / ... / Rel Homology Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 2

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / Rel Homology Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.16   (req: < 5)

Gene RIFs: 155   (req: <= 3)

Antibodies: 479   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.16   (req: >= 5)

Gene RIFs: 155   (req: > 3)

Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0