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Tbio
NFATC2
Nuclear factor of activated T-cells, cytoplasmic 2

Protein Summary
Description
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371564
  • ENSP00000360619
  • ENSG00000101096
  • ENST00000396009
  • ENSP00000379330
  • ENST00000414705
  • ENSP00000396471
  • ENST00000609507
  • ENSP00000477342
  • ENST00000609943
  • ENSP00000477370
  • ENST00000610033
  • ENSP00000477142

Symbol
  • NFAT1
  • NFATP
  • NFAT1
  • NFATP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
biological process
0.87
protein domain
0.85
molecular function
0.84
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 333   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 333   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.997
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.996
Data Source:  Reactome,STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.987
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.984
Data Source:  STRINGDB
IRF4
Tbio
Family:  TF
Novelty:  0.00192973
Score:  0.98
Data Source:  STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
Score:  0.972
Data Source:  Reactome,STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.969
Data Source:  STRINGDB
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
Score:  0.963
Data Source:  Reactome,STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
Score:  0.959
Data Source:  Reactome,STRINGDB
CABIN1
Tbio
Novelty:  0.02528794
Score:  0.959
Data Source:  STRINGDB
Pathways (69)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) induces NFAT activation
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Calcineurin activates NFAT
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) induces NFAT activation
CLEC7A (Dectin-1) signaling
Calcineurin activates NFAT
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
2
2
73.4
eosinophil count
2
2
2
73.4
systolic blood pressure
1
1
1
68
2
2
1
1
67.5
Varicose veins
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
73.4
eosinophil count
2
73.4
systolic blood pressure
1
68
1
1
67.5
Varicose veins
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T cells 2
VGNC:9897
469972
Macaque
nuclear factor of activated T-cells 2
710601
Mouse
MGI:102463
18019
Rat
RGD:1307690
311658
Dog
nuclear factor of activated T cells 2
VGNC:43767
485930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T cells 2
Macaque
nuclear factor of activated T-cells 2
Mouse
Rat
Dog
nuclear factor of activated T cells 2
Publication Statistics
PubMed Score 333.00
PubMed score by year
PubTator Score 215.95
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title