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Tbio
FZD5
Frizzled-5

Protein Summary
Description
Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and inter ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295417
  • ENSP00000354607
  • ENSG00000163251

Symbol
  • C2orf31
  • HFZ5
  • C2orf31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
co-expressed gene
0.99
transcription factor perturbation
0.94
transcription factor binding site profile
0.89
PubMedID
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.49   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.49   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.832675874
p_ni:  0.000003712
p_wrong:  0.167320414
Score:  0.2
Data Source:  BioPlex,STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.994
Data Source:  Reactome,STRINGDB
WNT7A
Tbio
Novelty:  0.00421662
Score:  0.987
Data Source:  STRINGDB
LRP6
Tbio
Novelty:  0.00305615
Score:  0.982
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.977
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.977
Data Source:  STRINGDB
ROR2
Tbio
Family:  Kinase
Novelty:  0.01698587
Score:  0.975
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.973
Data Source:  STRINGDB
WNT1
Tbio
Novelty:  0.00124301
Score:  0.972
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.972
Data Source:  STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
BRAF
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
EGFR
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
Pathways (75)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Ca2+ pathway
Class B/2 (Secretin family receptors)
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
47.7
hematocrit
2
1
2
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
47.7
hematocrit
2
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 5
VGNC:10809
470627
Mouse
MGI:108571
14367
Rat
RGD:631406
317674
Dog
frizzled class receptor 5
VGNC:41033
100855544
Cow
frizzled class receptor 5
VGNC:29169
538536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 5
Mouse
Rat
Dog
frizzled class receptor 5
Cow
frizzled class receptor 5
Publication Statistics
PubMed Score 56.49
PubMed score by year
PubTator Score 41.70
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title