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Tclin
ROCK1
Rho-associated protein kinase 1

Protein Summary
Description
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte termina ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399799
  • ENSP00000382697
  • ENSG00000067900

Symbol
  • ROCK-I
  • P160ROCK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
transcription factor perturbation
0.96
virus perturbation
0.94
disease perturbation
0.93


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 706.33   (req: < 5)
Gene RIFs: 315   (req: <= 3)
Antibodies: 605   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 706.33   (req: >= 5)
Gene RIFs: 315   (req: > 3)
Antibodies: 605   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 358
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
fasudil
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ripasudil
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GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
12.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho associated coiled-coil containing protein kinase 1
VGNC:7330
455326
Macaque
Rho associated coiled-coil containing protein kinase 1
698223
Mouse
MGI:107927
19877
Rat
RGD:620424
81762
Dog
Rho associated coiled-coil containing protein kinase 1
VGNC:45688
480181
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho associated coiled-coil containing protein kinase 1
Macaque
Rho associated coiled-coil containing protein kinase 1
Mouse
Rat
Dog
Rho associated coiled-coil containing protein kinase 1
Protein Structure (26 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13464-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 26
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (77)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Axon guidance
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Axon guidance
Developmental Biology
Gene Ontology Terms (72)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (217)
1 – 10 of 217
ROCK2
Tclin
Family:  Kinase
Novelty:  0.00242311
p_int:  0.999999679
p_ni:  3.3e-8
p_wrong:  2.89e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999999486
p_ni:  5.13e-7
p_wrong:  1e-9
Data Source:  BioPlex
MAGEB4
Tdark
Novelty:  0.2709865
p_int:  0.999839055
p_ni:  0.000160886
p_wrong:  5.9e-8
Score:  0.33
Data Source:  BioPlex,STRINGDB
ADD2
Tbio
Family:  Enzyme
Novelty:  0.01097975
p_int:  0.999785338
p_ni:  0.000211667
p_wrong:  0.000002995
Score:  0.852
Data Source:  BioPlex,STRINGDB
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.992847769
p_ni:  0.00034861
p_wrong:  0.00680362
Score:  0.17
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.995
Data Source:  Reactome,STRINGDB
PPP1R12A
Tbio
Family:  Enzyme
Novelty:  0.0028297
Score:  0.992
Data Source:  Reactome,STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.988
Data Source:  Reactome,STRINGDB
CFL1
Tbio
Novelty:  0.00071544
Score:  0.986
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.983
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  706.33

PubMed score by year
PubTator Score  323.38

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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