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Tbio
FOXE3
Forkhead box protein E3

Protein Summary
Description
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149). This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335071
  • ENSP00000334472
  • ENSG00000186790

Symbol
  • FKHL12
  • FREAC8
  • AAT11
  • ASGD2
  • FKHL12
  • FREAC8
  • CTRCT34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.57
biological process
0.54
tissue
0.5
phenotype
0.49
cell type or tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.58   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.58   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (56)
1 – 10 of 56
GPR161
Tbio
Family: GPCR
Novelty: 0.00508196
Score: 0.908
Data Source: STRINGDB
PITX3
Tbio
Family: TF
Novelty: 0.00594085
Score: 0.785
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00078251
Score: 0.752
Data Source: STRINGDB
PITX2
Tbio
Family: TF
Novelty: 0.00196459
Score: 0.663
Data Source: STRINGDB
B3GLCT
Tbio
Family: Enzyme
Novelty: 0.03109
Score: 0.644
Data Source: STRINGDB
C1QBP
Tbio
Novelty: 0.00278686
Score: 0.643
Data Source: STRINGDB
MAF
Tbio
Family: TF
Novelty: 0.00112851
Score: 0.608
Data Source: STRINGDB
SIX3
Tbio
Family: TF
Novelty: 0.00299273
Score: 0.587
Data Source: STRINGDB
MAB21L1
Tbio
Novelty: 0.10759186
Score: 0.57
Data Source: STRINGDB
VSX2
Tbio
Family: TF
Novelty: 0.0069303
Score: 0.566
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.58

PubMed score by year
PubTator Score  29.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer