Tbio TUSC3 Tumor suppressor candidate 3

Protein Summary

Description

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Magnesium transporter. This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]

Uniprot Accession IDs

• Q13454
• A8MSM0
• D3DSP2
• Q14911
• Q14912
• Q96FW0

Gene Name

• TUSC3

Ensembl ID

• ENST00000382020
• ENSP00000371450
• ENSG00000104723
• ENST00000503731
• ENSP00000424544

Symbol

• N33
• M33
• N33
• MRT7
• MRT22
• MagT2
• OST3A
• D8S1992

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
transcription factor perturbation	0.84
cellular component	0.75
pathway	0.74
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Tumor Suppressor Candidate 3

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc58 Magt-like Magnesium Transporter Family / Tumor Suppressor Candidate 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.93   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.93   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0