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Tchem
FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

Protein Classes
Protein Summary
Description
Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357266
  • ENSP00000349811
  • ENSG00000096060
  • ENST00000536438
  • ENSP00000444810
  • ENST00000539068
  • ENSP00000441205
  • ENST00000542713
  • ENSP00000442340

Symbol
  • AIG6
  • FKBP51
  • P54
  • AIG6
  • FKBP51
  • FKBP54
  • PPIase
  • Ptg-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.92
transcription factor perturbation
0.91
biological term
0.88
small molecule perturbation
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 404.45   (req: < 5)
Gene RIFs: 204   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 404.45   (req: >= 5)
Gene RIFs: 204   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (41)
1 – 5 of 41
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
ESR-mediated signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
ESR-mediated signaling
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (174)
1 – 10 of 174
CDK9
Tchem
Family: Kinase
Novelty: 0.00248764
p_int: 0.999990428
p_ni: 0.000009572
Score: 0.416
Data Source: BioPlex,STRINGDB
CDK11A
Tchem
Family: Kinase
Novelty: 0.02871406
p_int: 0.999989387
p_ni: 0.000010613
Score: 0.171
Data Source: BioPlex,STRINGDB
AGO1
Tbio
Novelty: 0.00268215
p_int: 0.999984227
p_ni: 0.000015773
Score: 0.383
Data Source: BioPlex,STRINGDB
CLK3
Tchem
Family: Kinase
Novelty: 0.02788904
p_int: 0.999982392
p_ni: 0.000017608
Score: 0.189
Data Source: BioPlex,STRINGDB
AMACR
Tbio
Family: Enzyme
Novelty: 0.0026828
p_int: 0.999959884
p_ni: 0.000040116
Score: 0.234
Data Source: BioPlex,STRINGDB
CDKL1
Tchem
Family: Kinase
Novelty: 0.15947257
p_int: 0.9999381
p_ni: 0.0000619
Score: 0.392
Data Source: BioPlex,STRINGDB
PSKH2
Tdark
Family: Kinase
p_int: 0.999840731
p_ni: 0.000159269
Score: 0.206
Data Source: BioPlex,STRINGDB
CDK7
Tchem
Family: Kinase
Novelty: 0.00400101
p_int: 0.999788021
p_ni: 0.000211979
Score: 0.164
Data Source: BioPlex,STRINGDB
CDK15
Tchem
Family: Kinase
Novelty: 3.88235294
p_int: 0.999782512
p_ni: 0.000217488
Score: 0.535
Data Source: BioPlex,STRINGDB
MAP3K6
Tchem
Family: Kinase
Novelty: 0.05352478
p_int: 0.999753751
p_ni: 0.000246249
Score: 0.339
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  404.45

PubMed score by year
PubTator Score  255.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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