FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5
Protein Summary
Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
- ENST00000357266
- ENSP00000349811
- ENSG00000096060
- ENST00000536438
- ENSP00000444810
- ENST00000539068
- ENSP00000441205
- ENST00000542713
- ENSP00000442340
- AIG6
- FKBP51
- P54
- AIG6
- FKBP51
- FKBP54
- PPIase
- Ptg-10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.97 | ||
protein domain | 0.92 | ||
transcription factor perturbation | 0.91 | ||
biological term | 0.88 | ||
small molecule perturbation | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 684.96 (req: < 5)
Gene RIFs: 315 (req: <= 3)
Antibodies: 411 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 684.96 (req: >= 5)
Gene RIFs: 315 (req: > 3)
Antibodies: 411 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 55
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2