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Tbio
LSAMP
Limbic system-associated membrane protein

Protein Summary
Description
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity). This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000490035
  • ENSP00000419000
  • ENSG00000185565

Symbol
  • IGLON3
  • LAMP
  • LAMP
  • IGLON3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
virus perturbation
0.68
microRNA
0.67
trait
0.61
disease
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.49   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.49   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999485443
p_ni:  0.000497906
p_wrong:  0.000016651
Score:  0.187
Data Source:  BioPlex,STRINGDB
NEGR1
Tbio
Novelty:  0.0088917
Score:  0.949
Data Source:  STRINGDB
NTM
Tbio
Novelty:  0.01659865
Score:  0.931
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.923
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.921
Data Source:  STRINGDB
CNTN5
Tbio
Novelty:  0.00601105
Score:  0.921
Data Source:  STRINGDB
CNTN4
Tbio
Novelty:  0.02483465
Score:  0.92
Data Source:  STRINGDB
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.918
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.914
Data Source:  STRINGDB
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.914
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean arterial pressure
1
1
1
64
diastolic blood pressure
2
1
2
59.8
1
1
1
59
self reported educational attainment
1
2
2
55.1
insomnia measurement
1
1
0
1.1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean arterial pressure
1
64
diastolic blood pressure
2
59.8
1
59
self reported educational attainment
2
55.1
insomnia measurement
0
1.1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
limbic system-associated membrane protein
713016
Mouse
MGI:1261760
268890
Rat
RGD:71102
29561
Dog
limbic system associated membrane protein
VGNC:42836
100683255
Horse
limbic system associated membrane protein
VGNC:19813
100061094
Species
Name
OMA
EggNOG
Inparanoid
Macaque
limbic system-associated membrane protein
Mouse
Rat
Dog
limbic system associated membrane protein
Horse
limbic system associated membrane protein
Publication Statistics
PubMed Score 80.49
PubMed score by year
PubTator Score 33.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title