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Tbio
ADAM15
Disintegrin and metalloproteinase domain-containing protein 15

Protein Summary
Description
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins kno ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271836
  • ENSP00000271836
  • ENSG00000143537
  • ENST00000355956
  • ENSP00000348227
  • ENST00000356955
  • ENSP00000349436
  • ENST00000359280
  • ENSP00000352226
  • ENST00000360674
  • ENSP00000353892
  • ENST00000368412
  • ENSP00000357397
  • ENST00000368413
  • ENSP00000357398
  • ENST00000447332
  • ENSP00000476000
  • ENST00000449910
  • ENSP00000403843
  • ENST00000526491
  • ENSP00000432347
  • ENST00000529473
  • ENSP00000434227
  • ENST00000531455
  • ENSP00000432927

Symbol
  • MDC15
  • MDC15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
protein domain
0.92
small molecule perturbation
0.8
histone modification site profile
0.79
molecular function
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.99   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 388   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.99   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0