You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GOLGA4
Golgin subfamily A member 4

Protein Summary
Description
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356847
  • ENSP00000349305
  • ENSG00000144674
  • ENST00000361924
  • ENSP00000354486

Symbol
  • GCP2
  • GOLG
  • p230
  • CRPF46
  • MU-RMS-40.18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor binding site profile
0.8
virus perturbation
0.68
histone modification site profile
0.66
biological process
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.56   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.56   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.99999977
p_ni:  2.31e-7
Data Source:  BioPlex
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999997999
p_ni:  0.000002
p_wrong:  1e-9
Data Source:  BioPlex
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999997386
p_ni:  0.000002614
Data Source:  BioPlex
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999995934
p_ni:  0.000004065
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.999993052
p_ni:  0.000006948
Data Source:  BioPlex
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999985009
p_ni:  0.000014991
Data Source:  BioPlex
LIMD1
Tbio
Novelty:  0.04868333
p_int:  0.999882706
p_ni:  0.000117289
p_wrong:  5e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
SMYD2
Tchem
Family:  Epigenetic
Novelty:  0.0192516
p_int:  0.999479602
p_ni:  0.000520397
Score:  0.455
Data Source:  BioPlex,STRINGDB
UTP4
Tbio
Novelty:  0.06989008
p_int:  0.999279065
p_ni:  0.000720935
Score:  0.527
Data Source:  BioPlex,STRINGDB
NOL11
Tbio
Novelty:  0.47253767
p_int:  0.992185925
p_ni:  0.007814024
p_wrong:  5.1e-8
Score:  0.558
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
2
2
65.9
heel bone mineral density
2
1
2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
65.9
heel bone mineral density
2
42.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgin A4
VGNC:1828
460264
Macaque
golgin A4
697455
Mouse
MGI:1859646
54214
Rat
RGD:1591925
501069
Dog
golgin A4
VGNC:41340
477020
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgin A4
Macaque
golgin A4
Mouse
Rat
Dog
golgin A4
Publication Statistics
PubMed Score 64.56
PubMed score by year
PubTator Score 46.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title