You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
OS9
Protein OS-9

Protein Summary
Description
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257966
  • ENSP00000257966
  • ENSG00000135506
  • ENST00000315970
  • ENSP00000318165
  • ENST00000389142
  • ENSP00000373794
  • ENST00000389146
  • ENSP00000373798
  • ENST00000435406
  • ENSP00000389632
  • ENST00000439210
  • ENSP00000407360
  • ENST00000551035
  • ENSP00000447866
  • ENST00000552285
  • ENSP00000450010

Symbol
  • OS-9
  • ERLEC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.88
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
cellular component
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.22   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.22   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
94
urate measurement
1
3
3
89.3
apolipoprotein A 1 measurement
1
2
2
72.6
high density lipoprotein cholesterol measurement
1
2
2
71.6
mathematical ability
2
2
2
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94
urate measurement
3
89.3
apolipoprotein A 1 measurement
2
72.6
high density lipoprotein cholesterol measurement
2
71.6
mathematical ability
2
57.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
OS9, endoplasmic reticulum lectin
VGNC:10409
452022
Macaque
OS9, endoplasmic reticulum lectin
715555
Mouse
MGI:1924301
216440
Rat
RGD:1359574
362891
Dog
OS9, endoplasmic reticulum lectin
VGNC:44148
474419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
OS9, endoplasmic reticulum lectin
Macaque
OS9, endoplasmic reticulum lectin
Mouse
Rat
Dog
OS9, endoplasmic reticulum lectin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13438-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Defective CFTR causes cystic fibrosis
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Defective CFTR causes cystic fibrosis
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (261)
1 – 10 of 261
EMILIN2
Tbio
Novelty:  0.2816786
p_int:  0.999976478
p_ni:  0.000023466
p_wrong:  5.7e-8
Data Source:  BioPlex
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
p_int:  0.999959557
p_ni:  0.000040349
p_wrong:  9.5e-8
Score:  0.739
Data Source:  BioPlex,STRINGDB
ZNFX1
Tdark
Novelty:  0.06228436
p_int:  0.999948886
p_ni:  0.000020852
p_wrong:  0.000030262
Data Source:  BioPlex
ADAMTS17
Tbio
Family:  Enzyme
Novelty:  0.04568792
p_int:  0.999809147
p_ni:  0.00004304
p_wrong:  0.000147813
Data Source:  BioPlex
AGRN
Tbio
Novelty:  0.00156441
p_int:  0.999626037
p_ni:  0.00035002
p_wrong:  0.000023943
Data Source:  BioPlex
LIFR
Tbio
Novelty:  0.00514085
p_int:  0.999320333
p_ni:  0.000322411
p_wrong:  0.000357256
Data Source:  BioPlex
BMP8B
Tbio
Novelty:  0.00329096
p_int:  0.999133041
p_ni:  0.00040188
p_wrong:  0.000465079
Data Source:  BioPlex
LAMA5
Tbio
Novelty:  0.02247145
p_int:  0.998849301
p_ni:  0.0011507
Data Source:  BioPlex
NTN1
Tbio
Novelty:  0.00183678
p_int:  0.998798563
p_ni:  0.000981741
p_wrong:  0.000219696
Data Source:  BioPlex
SULF1
Tbio
Family:  Enzyme
Novelty:  0.00992209
p_int:  0.998629041
p_ni:  0.001363618
p_wrong:  0.000007342
Data Source:  BioPlex
Publication Statistics
PubMed Score  66.22

PubMed score by year
PubTator Score  34.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: