Tdark MKRN4P Putative E3 ubiquitin-protein ligase makorin-4

Protein Summary

Description

May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Uniprot Accession IDs

• Q13434

Gene Name

• MKRN4P

Symbol

• MKRN4
• MKRNP5
• RNF64
• ZNF127L1
• MKRN4
• RNF64
• MKRNP5
• ZNF-Xp
• ZNF127L1
• ZNF127-Xp

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.65
transcription factor	0.63
cellular component	0.52
biological process	0
biological term	0

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Putative E3 Ubiquitin-protein Ligase Makorin-4

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Putative E3 Ubiquitin-protein Ligase Makorin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0