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Tbio
SLC39A6
Zinc transporter ZIP6

Protein Summary
Description
May act as a zinc-influx transporter. Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269187
  • ENSP00000269187
  • ENSG00000141424
  • ENST00000440549
  • ENSP00000401139
  • ENST00000590986
  • ENSP00000465915

Symbol
  • LIV1
  • ZIP6
  • ZIP6
  • LIV-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.79
kinase perturbation
0.76
histone modification site profile
0.75
transcription factor binding site profile
0.73


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.51   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.51   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
52.6
1
1
0
1.3
52.6
survival time
1
1
0
1.3
52.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
52.6
0
1.3
52.6
survival time
0
1.3
52.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 6
VGNC:7818
468523
Macaque
solute carrier family 39 member 6
709313
Mouse
MGI:2147279
106957
Rat
RGD:1304664
291733
Dog
solute carrier family 39 member 6
VGNC:46405
480159
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 6
Macaque
solute carrier family 39 member 6
Mouse
Rat
Dog
solute carrier family 39 member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13433-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc influx into cells by the SLC39 gene family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc influx into cells by the SLC39 gene family
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (51)
1 – 10 of 51
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
p_int: 0.99846738
p_ni: 0.00153262
Score: 0.451
Data Source: BioPlex,STRINGDB
LPCAT2
Tbio
Family: Enzyme
Novelty: 0.02794035
p_int: 0.972842848
p_ni: 0.027157152
Data Source: BioPlex
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
p_int: 0.858945443
p_ni: 0.141054557
Score: 0.173
Data Source: BioPlex,STRINGDB
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
Score: 0.853
Data Source: STRINGDB
SLC30A6
Tbio
Family: Transporter
Novelty: 0.06083299
Score: 0.851
Data Source: STRINGDB
SLC39A1
Tbio
Family: Transporter
Novelty: 0.00678191
Score: 0.833
Data Source: STRINGDB
SLC30A5
Tbio
Family: Transporter
Novelty: 0.02432633
Score: 0.832
Data Source: STRINGDB
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
Score: 0.805
Data Source: STRINGDB
SLC39A2
Tbio
Family: Transporter
Novelty: 0.01886854
Score: 0.798
Data Source: STRINGDB
SLC30A4
Tbio
Family: Transporter
Novelty: 0.02209
Score: 0.779
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.51

PubMed score by year
PubTator Score  52.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer