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Tbio
TCOF1
Treacle protein

Protein Summary
Description
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323668
  • ENSP00000325223
  • ENSG00000070814
  • ENST00000377797
  • ENSP00000367028
  • ENST00000394269
  • ENSP00000377811
  • ENST00000427724
  • ENSP00000390717
  • ENST00000439160
  • ENSP00000406888
  • ENST00000445265
  • ENSP00000409944
  • ENST00000504761
  • ENSP00000421655
  • ENST00000642994
  • ENSP00000494375
  • ENST00000643257
  • ENSP00000493815

Symbol
  • TCS
  • MFD1
  • TCS1
  • treacle
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
disease perturbation
0.96
interacting protein
0.95
co-expressed gene
0.93
transcription factor perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.8   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.8   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
33.1
gut microbiome measurement
1
1
0
3.3
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
33.1
gut microbiome measurement
0
3.3
21.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
treacle ribosome biogenesis factor 1
VGNC:13606
471696
Macaque
treacle ribosome biogenesis factor 1
664735
Mouse
MGI:892003
21453
Rat
RGD:1309850
291571
Dog
treacle ribosome biogenesis factor 1
VGNC:47206
403592
Species
Name
OMA
EggNOG
Inparanoid
Chimp
treacle ribosome biogenesis factor 1
Macaque
treacle ribosome biogenesis factor 1
Mouse
Rat
Dog
treacle ribosome biogenesis factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13428-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (92)
1 – 10 of 92
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.982570814
p_ni:  0.017429186
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.970451891
p_ni:  0.029548109
Data Source:  BioPlex
DENND2D
Tbio
Novelty:  0.16496649
p_int:  0.967086142
p_ni:  0.032913858
Score:  0.201
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.932725229
p_ni:  0.067274771
p_wrong:  1e-9
Data Source:  BioPlex
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
p_int:  0.91340282
p_ni:  0.086597181
Data Source:  BioPlex
ARRB1
Tbio
Novelty:  0.00262758
p_int:  0.778818439
p_ni:  0.221181561
Score:  0.28
Data Source:  BioPlex,STRINGDB
TARBP2
Tbio
Novelty:  0.01485994
Score:  0.802
Data Source:  STRINGDB
POLR1D
Tbio
Family:  Enzyme
Novelty:  0.01598347
Score:  0.753
Data Source:  STRINGDB
POLR1D
Tbio
Novelty:  0.01598347
Score:  0.753
Data Source:  STRINGDB
PRKRA
Tbio
Family:  Kinase
Novelty:  0.02115618
Score:  0.744
Data Source:  STRINGDB
Publication Statistics
PubMed Score  149.80

PubMed score by year
PubTator Score  171.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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