Protein Summary
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep ...more
- ENST00000323668
- ENSP00000325223
- ENSG00000070814
- ENST00000377797
- ENSP00000367028
- ENST00000394269
- ENSP00000377811
- ENST00000427724
- ENSP00000390717
- ENST00000439160
- ENSP00000406888
- ENST00000445265
- ENSP00000409944
- ENST00000504761
- ENSP00000421655
- ENST00000642994
- ENSP00000494375
- ENST00000643257
- ENSP00000493815
- TCS
- MFD1
- TCS1
- treacle
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
disease perturbation | 0.96 | ||
interacting protein | 0.95 | ||
co-expressed gene | 0.93 | ||
transcription factor perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 149.8 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 177 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 149.8 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 177 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (92)
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.982570814
p_ni: 0.017429186
Data Source: BioPlex
PIP4K2A
Family: Kinase
Novelty: 0.01130885
p_int: 0.970451891
p_ni: 0.029548109
Data Source: BioPlex
DENND2D
Novelty: 0.16496649
p_int: 0.967086142
p_ni: 0.032913858
Score: 0.201
Data Source: BioPlex,STRINGDB
FGF12
Novelty: 0.02094849
p_int: 0.932725229
p_ni: 0.067274771
p_wrong: 1e-9
Data Source: BioPlex
PLCD4
Family: Enzyme
Novelty: 0.07014141
p_int: 0.91340282
p_ni: 0.086597181
Data Source: BioPlex
ARRB1
Novelty: 0.00262758
p_int: 0.778818439
p_ni: 0.221181561
Score: 0.28
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Ribosome biogenesis in eukaryotes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ribosome biogenesis in eukaryotes | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (5)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 1 | 1 | 1 | 33.1 | |||||
gut microbiome measurement | 1 | 1 | 0 | 3.3 | 21.5 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 1 | 33.1 | |||||
gut microbiome measurement | 0 | 3.3 | 21.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | treacle ribosome biogenesis factor 1 | VGNC:13606 | 471696 | |||||
Macaque | treacle ribosome biogenesis factor 1 | 664735 | ||||||
Mouse | MGI:892003 | 21453 | ||||||
Rat | RGD:1309850 | 291571 | ||||||
Dog | treacle ribosome biogenesis factor 1 | VGNC:47206 | 403592 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | treacle ribosome biogenesis factor 1 | |||||
Macaque | treacle ribosome biogenesis factor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | treacle ribosome biogenesis factor 1 | |||||
Publication Statistics
PubMed Score 149.80
PubMed score by year
PubTator Score 171.84
PubTator score by year
Related Publications
Text Mined References (62)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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