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Tchem
PPIG
Peptidyl-prolyl cis-trans isomerase G

Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260970
  • ENSP00000260970
  • ENSG00000138398
  • ENST00000448752
  • ENSP00000407083
  • ENST00000462903
  • ENSP00000435987

Symbol
  • CYP
  • SRCyp
  • SCAF10
  • CARS-Cyp
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
disease perturbation
0.79
hub protein
0.75
kinase
0.72
transcription factor binding site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6111.41   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6111.41   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
45.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
45.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase G
VGNC:14343
459718
Macaque
peptidylprolyl isomerase G
706262
Mouse
MGI:2445173
228005
Rat
RGD:620315
83624
Dog
peptidylprolyl isomerase G
VGNC:44853
607519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase G
Macaque
peptidylprolyl isomerase G
Mouse
Rat
Dog
peptidylprolyl isomerase G
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13427-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (266)
1 – 10 of 266
PNN
Tbio
Novelty: 0.01395394
p_int: 0.999695211
p_ni: 0.000303871
p_wrong: 9.18e-7
Score: 0.91
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.998802512
p_ni: 0.001197154
p_wrong: 3.34e-7
Data Source: BioPlex
CLK3
Tchem
Family: Kinase
Novelty: 0.03466191
p_int: 0.997282301
p_ni: 0.002698666
p_wrong: 0.000019032
Score: 0.766
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.996346327
p_ni: 0.003651884
p_wrong: 0.000001789
Score: 0.331
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.996309244
p_ni: 0.003690756
Score: 0.298
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.996229896
p_ni: 0.003770104
Score: 0.173
Data Source: BioPlex,STRINGDB
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.99599019
p_ni: 0.003984247
p_wrong: 0.000025563
Score: 0.668
Data Source: BioPlex,STRINGDB
SNIP1
Tbio
Novelty: 0.01865867
p_int: 0.995925157
p_ni: 0.004049398
p_wrong: 0.000025445
Score: 0.673
Data Source: BioPlex,STRINGDB
SAP18
Tbio
Family: Enzyme
Novelty: 0.03918373
p_int: 0.993929444
p_ni: 0.002273582
p_wrong: 0.003796974
Data Source: BioPlex
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.982634171
p_ni: 0.017323797
p_wrong: 0.000042032
Data Source: BioPlex
Publication Statistics
PubMed Score  6111.41

PubMed score by year
PubTator Score  418.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer