Tchem PPIG Peptidyl-prolyl cis-trans isomerase G

Protein Summary

Description

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

Uniprot Accession IDs

• Q13427
• D3DPC5
• D3DPC6
• O00706
• Q53R40
• Q53SN4
• Q96DG9
• PPIase G

Gene Name

• PPIG

Ensembl ID

• ENST00000260970
• ENSP00000260970
• ENSG00000138398
• ENST00000448752
• ENSP00000407083
• ENST00000462903
• ENSP00000435987

Symbol

• CYP
• SRCyp
• SCAF10
• CARS-Cyp

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
disease perturbation	0.79
hub protein	0.75
kinase	0.72
transcription factor binding site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7353.76   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7353.76   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0