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Tbio
SNTB2
Beta-2-syntrophin

Protein Summary
Description
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336278
  • ENSP00000338191
  • ENSG00000168807
  • ENST00000467311
  • ENSP00000436443
  • ENST00000562438
  • ENSP00000458999
  • ENSG00000260873

Symbol
  • D16S2531E
  • SNT2B2
  • SNTL
  • SNT3
  • SNTL
  • SNT2B2
  • EST25263
  • D16S2531E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.9
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83
microRNA
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.26   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.26   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (56)
1 – 10 of 56
SNTG2
Tbio
Novelty: 0.04056715
p_int: 0.999999914
p_ni: 8.5e-8
p_wrong: 1e-9
Score: 0.94
Data Source: BioPlex,STRINGDB
DMD
Tclin
Novelty: 0.00025661
p_int: 0.999999746
p_ni: 2.51e-7
p_wrong: 3e-9
Score: 0.962
Data Source: BioPlex,STRINGDB
SNTG1
Tbio
Novelty: 0.05608114
p_int: 0.999998904
p_ni: 0.000001096
Score: 0.823
Data Source: BioPlex,STRINGDB
DTNB
Tbio
Novelty: 0.0586565
p_int: 0.999997981
p_ni: 0.000002019
Score: 0.718
Data Source: BioPlex,STRINGDB
NDEL1
Tbio
Novelty: 0.01241819
p_int: 0.999894827
p_ni: 0.000105144
p_wrong: 2.9e-8
Data Source: BioPlex
RHPN1
Tbio
Novelty: 0.05722992
p_int: 0.999810703
p_ni: 0.000189297
Data Source: BioPlex
HMG20A
Tbio
Family: TF
Novelty: 0.11994252
p_int: 0.999794894
p_ni: 0.000205105
p_wrong: 1e-9
Data Source: BioPlex
TAGAP
Tbio
Family: Enzyme
Novelty: 0.04450409
p_int: 0.999655526
p_ni: 0.000344474
Data Source: BioPlex
CPNE5
Tbio
Novelty: 0.09416684
p_int: 0.999653775
p_ni: 0.000346224
p_wrong: 1e-9
Data Source: BioPlex
CFAP36
Tdark
Novelty: 0.42842118
p_int: 0.9959379
p_ni: 0.004062095
p_wrong: 5e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.26

PubMed score by year
PubTator Score  9.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer