You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NNT
NAD(P) transhydrogenase, mitochondrial

Protein Summary
Description
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264663
  • ENSP00000264663
  • ENSG00000112992
  • ENST00000344920
  • ENSP00000343873

Symbol
  • GCCD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.94
molecular function
0.88
histone modification site profile
0.73
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.04   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.04   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
7.7
pulse pressure measurement
1
1
1
3.7
apolipoprotein A 1 measurement
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
7.7
pulse pressure measurement
1
3.7
apolipoprotein A 1 measurement
1
0.6
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (69)
1 – 10 of 69
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01137558
p_int: 0.999989761
p_ni: 0.000010239
Score: 0.181
Data Source: BioPlex,STRINGDB
GPRC5C
Tbio
Family: GPCR
Novelty: 0.16942353
p_int: 0.994608812
p_ni: 0.005391188
Score: 0.161
Data Source: BioPlex,STRINGDB
SUSD4
Tbio
Novelty: 0.22201938
p_int: 0.964277547
p_ni: 0.035722453
Score: 0.169
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.894001201
p_ni: 0.105998799
Data Source: BioPlex
NADK
Tbio
Family: Kinase
Novelty: 0.02812925
Score: 0.952
Data Source: STRINGDB
NMNAT3
Tbio
Family: Enzyme
Novelty: 0.03261313
Score: 0.945
Data Source: STRINGDB
NADK2
Tbio
Family: Kinase
Novelty: 0.12395524
Score: 0.938
Data Source: STRINGDB
NADSYN1
Tbio
Family: Enzyme
Novelty: 0.0445844
Score: 0.93
Data Source: STRINGDB
NMNAT1
Tbio
Family: Enzyme
Novelty: 0.01110899
Score: 0.925
Data Source: STRINGDB
NMNAT2
Tbio
Family: Enzyme
Novelty: 0.01709189
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  364.04

PubMed score by year
PubTator Score  21.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: